PMID: 8583539Aug 1, 1995Paper

Comparative plasma and tissue pharmacokinetics and drug residue profiles of different chemotherapeutants in fowls and rabbits

Journal of Veterinary Pharmacology and Therapeutics
T LiS Y Li

Abstract

Blood and tissue pharmacokinetics and drug residue profiles of six chemotherapeutants were studied. Ceftriaxone (CEF), intravenously at 50 mg/kg, sulfamonomethoxine (SMM) and sulfaquinoxaline (SQ), orally at 200 mg/kg, and olaquindox (OLA), orally at 50 mg/kg, were administered to young broilers. Penicillin (PEN), intramuscularly at 200,000 U/kg, and albendazole (ALB), orally at 20 mg/kg, were given to rabbits. For each drug, 13-18 groups (n = 5-10 individuals/group) of the dosed animals were killed at different post-dosing times. Drug and/or metabolite concentrations in plasma, liver, kidney, heart, lung, and muscle tissues were analysed by HPLC procedures. Multi-exponential kinetic models were fitted to the observed tissue concentration-time data by applying a non-linear least-squares regression computer program. Tissue half-life, peak tissue concentration, and time of peak tissue concentration were determined. Half-life of CEF, SMM, SQ, OLA, PEN, ALB, and two metabolites of ALB (sulfoxide and sulfone) in various tissues ranged 0.6-1.4, 4.7-9.0, 4.5-18.9, 1.8-3.1, 0.9-3.0, 3.4-9.6, 5.0-16.1 and 7.4-12.2 h. The times required for CEF, SMM, SQ, OLA, PEN, and ALB residue concentrations to decline to 0.1 microgram/g in various ti...Continue Reading

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Citations

Dec 16, 2003·Research in Veterinary Science·J VelíkL Skálová
Nov 6, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ismail Sentepe, Gökhan Eraslan
Jul 6, 2007·Journal of Veterinary Pharmacology and Therapeutics·G A AlbarellosM F Landoni
Sep 25, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Giulia SegatoCristiana Benetti
Aug 5, 2018·Journal of Veterinary Pharmacology and Therapeutics·Trishna PatelLisa A Tell

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