PMID: 789082Sep 30, 1976Paper

Comparative potency of atenolol and propranolol as beta-adrenergic blocking agents in man

European Journal of Clinical Pharmacology
J F De PlaenT Reybrouck

Abstract

The comparative potency of two beta-blockers, propranolol and atenolol, in the inhibition of exercise tachycardia and isoproterenol-tachycardia has been studied in two groups of hypertensive patients, using oral doses which were increased weekly. A linear correlation was observed between the reduction in exercise tachycardia and the dose of each drug, up to a daily dose of propranolol 480 mg and atenolol 600 mg. Propranolol was slightly (0.7/1) more potent in decreasing maximal exercise tachycardia than atenolol when tested in low doses (below 100 mg); at higher doses (480 mg) no differences were found. However, atenolol was 10 times less potent than propranolol in blocking isoprenaline-induced tachycardia, which seems to be related to the cardioselectivity of atenolol.

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Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·S H ThomasS E Smith
Dec 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C Nyarko-Adomfeh
Apr 16, 1986·European Journal of Pharmacology·H J SchliepG Haeusler
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Oct 5, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nazareth Eliana CeschanHugh David Charles Smyth
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