PMID: 11342897May 9, 2001Paper

Comparative predictive values of urinary cytology, urinary bladder cancer antigen, CYFRA 21-1 and NMP22 for evaluating symptomatic patients at risk for bladder cancer

The Journal of Urology
Marta Sanchez-CarbayoJ A Navajo

Abstract

We study the potential diagnostic use of urinary bladder cancer antigen, CYFRA 21-1 and NMP22*; for evaluating symptomatic patients who present with microscopic hematuria and are at risk for bladder cancer. Urinary tumor markers were determined in 187 samples from 112 patients symptomatic of bladder cancer (group 1), and 75 with benign and other urological conditions (group 2). Immunoassays were used to measure the 3 selected biomarkers. Sensitivity and specificity were established by previously defined cut points. Biomarker results were reported as corrected and uncorrected for urinary creatinine. Urinalysis was performed in all samples. Positive and negative predictive values were 85.5%, 80.5% and 81.1%, and 80.8%, 79.2% and 76.5% for urinary bladder cancer antigen, CYFRA 21-1 and NMP22, with the cutoffs 9.7 microg./l., 5.4 microg./l and 10.0 units per ml., respectively. These predictives values were 85.2% and 72.5%, respectively, for urinary cytology. The combination of biomarkers decreased the positive predictive values to 72.3% to 78.6% and increased negative predictive values to 84.2% to 86.1%. Urinary tract infection, inflammation and malignancy associated with other genitourinary organs were the primary cause for false-...Continue Reading

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Citations

Jul 19, 2005·Journal of Clinical Laboratory Analysis·Daniel Fatela-CantilloXavier Filella
Dec 7, 2007·World Journal of Urology·Edmund ChiongH Barton Grossman
Jan 16, 2014·Indian Journal of Clinical Biochemistry : IJCB·Ragaa H M SalamaSally M Bakar
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Aug 8, 2006·The Journal of Urology·Shahrokh F ShariatPierre I Karakiewicz
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Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C BlackColin P Dinney
Jan 15, 2014·Urologia·Fabrizio Dal MoroFiliberto Zattoni

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