Comparative Proliferation Capacity of Gag-C-Specific Naive and Memory CD4+ and CD8+ T Lymphocytes in Rapid, Viremic Slow, and Slow Progressors During Human Immunodeficiency Virus Infection

Viral Immunology
Neema NegiMadhu Vajpayee

Abstract

The exact cause of altered dynamics in T cells compartment during HIV infection remains elusive to date. In this longitudinal study, the proliferation frequency of different T cell subsets was investigated in untreated HIV-1-infected Indian individuals stratified as rapid (R), viremic slow (VS), slow (S) progressors, and healthy controls. Ten healthy and 20 treatment-naive HIV-1-infected individuals were enrolled. Expression of Ki67 nuclear antigen was examined on HIV-specific T cell subsets in peripheral blood lymphocytes. Upon stimulation with HIV-1 Gag-C peptide pools, effector memory (EM) CD4 T cells (R vs. S, EM CD4, p < 0.05) of R progressors proliferated significantly compared with those of S progressors at baseline. However, central memory (CM) CD8 T cell subsets proliferated significantly in VS and S progressors compared with those in R progressors, wherein highest proliferation frequency of EM CD8 T cells was observed. At follow-up visit, the proliferation frequency of naive CD8 T cells was significantly higher in R progressors than S progressors (R vs. S naive CD8, p < 0.05). The findings suggest altered dynamics of different CD4+ and CD8+ T cell subsets in R, VS, and S progressors. The increase in CM T cell prolifer...Continue Reading

References

May 1, 1995·The Journal of Clinical Investigation·M RoedererL A Herzenberg
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z Q ZhangA T Haase
Jul 4, 1998·Radiation Oncology Investigations·P C Keng, D W Siemann
Mar 23, 2001·Nature Immunology·M D HazenbergF Miedema
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ruy M RibeiroAlan S Perelson
Dec 17, 2003·The Journal of Experimental Medicine·Souheil-Antoine YounesRafick-Pierre Sekaly
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marta CatalfamoH Clifford Lane
Jun 17, 2010·PloS One·Concepción CasadoCecilio López-Galíndez
Aug 31, 2010·Journal of Immunological Methods·Andreia SoaresWillem A Hanekom
Jun 23, 2011·Cytometry. Part B, Clinical Cytometry·Kamalika MojumdarSravya Kurapati
Feb 9, 2012·The Indian Journal of Medical Research·Kamalika MojumdarSravya Kurapati
Jun 19, 2013·Immunological Reviews·Afam A Okoye, Louis J Picker
Mar 30, 2016·Current Opinion in HIV and AIDS·Guinevere Q Lee, Mathias Lichterfeld

❮ Previous
Next ❯

Citations

May 24, 2019·Journal of Translational Medicine·Ying PanHong Shang

❮ Previous
Next ❯

Software Mentioned

Tree Star
FlowJo
STATA

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.