Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos

Toxicology and Applied Pharmacology
K A BéruBéB T Mossman

Abstract

Patterns of cell proliferation in lung and pleura and development of histopathologic lesions were studied in lungs from Fischer 344 rats after inhalation exposure to chrysotile or crocidolite asbestos at average airborne concentrations of approximately 8 mg/m3 air for 5 and 20 days and after 20 days of exposure followed by an additional 20 days in room air (20 + 20 days). To assess cell proliferation rats were injected with 5-bromo-2'-deoxyuridine (BrdU) at various time points after initiation of exposure to asbestos. Image analysis was used to quantitate the effects of chrysotile and crocidolite on BrdU labeling indices in the following lung compartments: (1) interstitium, (2) alveolar duct region, (3) bronchial epithelium, and (4) visceral mesothelium. With the exception of mesothelium, which exhibited significant increases in BrdU incorporation in rats exposed to crocidolite at 20 + 20 days, asbestos-induced elevations in BrdU uptake in other compartments were transient with labeling comparable to sham controls at later time points. Histopathology of rat lungs revealed fibrotic lesions of a greater extent and severity at 20 days in rats exposed to crocidolite, but fibrosis occurred in both asbestos-exposed groups after an ad...Continue Reading

Citations

May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brooke T MossmanJames C Bonner
Feb 16, 2010·Journal of Toxicology and Environmental Health. Part a·Maricica PacurariVal Vallyathan
Mar 7, 2001·Antioxidants & Redox Signaling·N K FukagawaB T Mossman
Sep 15, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lorriana E Leard, V Courtney Broaddus
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·B T Mossman, A Churg
Oct 6, 1997·American Journal of Respiratory Cell and Molecular Biology·J L GoldbergB T Mossman
Jan 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Brooke T Mossman, Dieter C Gruenert
Aug 4, 2007·American Journal of Respiratory Cell and Molecular Biology·Jamie LevisDaniel J Weiss
Apr 7, 2000·Environmental Health Perspectives·B RihnG Keith
Sep 17, 2008·Environmental Health Perspectives·Naomi K FukagawaBrooke T Mossman
Dec 24, 1997·Environmental Health Perspectives·B T MossmanK Driscoll
Apr 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Arti ShuklaBrooke T Mossman
Jul 8, 1999·Journal of Cellular Physiology·R Robledo, B Mossman
Jul 26, 2005·Inhalation Toxicology·David BernsteinUNKNOWN ILSI Risk Science Institute Working Group
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Astrid HaegensBrooke T Mossman

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