Comparative Proteomic Analyses of the Liver in D-Galactosamine-Sensitized Mice Treated with Different Toll-Like Receptor Agonists.

Proteomics
Jun HaoJinjun Chen

Abstract

Acute liver failure (ALF) is a severe consequence of abrupt hepatocyte injury and has lethal outcomes. Three toll-like receptor agonists, including polyinosinic-polycytidylic acid (poly(I:C)), lipopolysaccharide (LPS), and cytosine-phosphate-guanine (CpG) DNA, cause acute and severe hepatitis, respectively, in D-galactosamine (D-GalN)-sensitized mice. However, the molecular differences among three ALF models (LPS/D-GalN, poly(I:C)/D-GalN, and CpG DNA/D-GalN), are unclear. Here, tandem mass tag based quantitative proteomic analyses of three ALF mouse models are performed. 52 common differentially expressed proteins (DEPs) are identified, in three ALF groups, compared to the control. Gene ontology analyses show that among the common DEPs, ten proteins are involved in immune system process, and 39 proteins in metabolic process. Among 80,195, and 23 specifically-expressed proteins in poly(I:C)/D-GalN, LPS/D-GalN, and CpG DNA/D-GalN groups, LPS/D-GalN-specific proteins are mostly distributed in the endoplasmic reticulum and more enriched in metabolic pathways, whereas poly (I:C)/D-GalN-specific proteins are mainly in the membrane and CpG DNA/D-GalN-specific proteins are related to the ribosome structural composition. In conclusion, ...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Oct 1, 1968·Experimental and Molecular Pathology·D KepplerK Decker
Oct 29, 1997·The Journal of Veterinary Medical Science·S TsutsuiK Doi
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A MignonV Joulin
Dec 29, 2000·Nature·H HemmiS Akira
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Feb 29, 2008·Drug Metabolism and Pharmacokinetics·Frank J Gonzalez
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xin HouZhigang Tian
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Nov 30, 2011·The Journal of Physiology·Ekihiro Seki, Bernd Schnabl
Dec 27, 2013·The New England Journal of Medicine·William Bernal, Julia Wendon
Mar 17, 2015·The Journal of Clinical Investigation·Taichiro NishikawaIra J Fox
Apr 8, 2015·Current Protocols in Immunology·Kiyoshi Takeda, Shizuo Akira
Apr 29, 2015·Journal of Hepatology·William BernalRoger Williams
Jul 24, 2015·Hepatology International·Shiv Kumar SarinUNKNOWN APASL ACLF Working Party
Sep 27, 2018·Nucleic Acids Research·Jie MaYunping Zhu
Sep 10, 2019·Lancet·R Todd Stravitz, William M Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Cranio : the Journal of Craniomandibular Practice
Tasha Turzo
Seminars in Respiratory and Critical Care Medicine
Priyanka Rajaram, Ram M Subramanian
Metabolic Brain Disease
Mireille Bélanger, Roger F Butterworth
Journal of Clinical and Experimental Hepatology
Shalimar
Current Gene Therapy
Chuan-Long ZhuRen-Tao Gao
© 2021 Meta ULC. All rights reserved