Comparative proteomic analyses of urine from rat urothelial carcinoma chemically induced by exposure to N-butyl-N-(4-hydroxybutyl)-nitrosamine

Molecular BioSystems
Rita FerreiraRui Vitorino

Abstract

Bladder cancer is estimated to be the ninth most common malignancy with a high rate of recurrence and progression despite therapy, early diagnosis being crucial for timely intervention. Using a well-established animal model of urothelial carcinoma, we performed a comprehensive analysis of urine proteome profile from healthy animals and animals with urothelial carcinoma at two time-points of disease pathogenesis. GeLC-MS/MS, followed by bioinformatics analysis of unique proteins and the ones present in significantly distinct levels among groups, highlighted the biological processes involved in disease pathogenesis such as, for instance, response to selenium and to drugs, neutral lipid metabolism at earlier stages of disease, and inflammation, immune response and wound healing at advanced stages. Proteins from up-regulated biological processes might be seen as putative disease biomarkers. These include, for example, cadherins, lipoproteins, and glysosyltransferases, which may be included in multimarker strategies. Taken together, the data support the application of urine proteomics for the identification of the biological processes modulated by bladder cancer in an integrative perspective. The present exploratory urinary proteomi...Continue Reading

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Citations

May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Maria Camila AlmeidaDaniel Carneiro Carrettiero
Mar 10, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Carina BernardoLúcio Lara Santos
Apr 8, 2016·Clinical and Translational Medicine·Björn L D M BrücherIjaz S Jamall
Jun 2, 2021·Expert Review of Proteomics·Jing Wei, Youhe Gao
Jun 25, 2021·Journal of Nanobiotechnology·Jianye LiuKe Cao

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