Comparative proteomic analysis of Salmonella tolerance to the biocide active agent triclosan

Journal of Proteomics
Orla CondellJ E Nally

Abstract

Concern has been expressed about the overuse of biocides in farm animal production and food industries. Biocide application can create selective pressures that lead to increased tolerance to one or more of these compounds and are concomitant with the emergence of cross-resistance to antibiotics. A triclosan sensitive Salmonella enterica serovar Typhimurium and the isogenic triclosan tolerant mutant were studied at the proteomic level in order to elucidate cellular mechanisms that facilitate biocide tolerance. 2-D differential fluorescent gel electrophoresis (DIGE) compared protein profiles of parent and mutant Salmonella, in the presence and absence of triclosan. Differentially expressed proteins were identified by mass spectrometry and divided into two groups: Group A describes proteins differentially expressed between susceptible and triclosan tolerant Salmonella and includes the known triclosan target FabI which contained a mutation at the triclosan target binding site. Group B identified proteins differentially expressed in response to triclosan exposure and defines a general cell defence network. Only four proteins were common to both groups highlighting the diverse range of pathways employed by Salmonella to counteract bi...Continue Reading

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Citations

Dec 10, 2013·Journal of Proteomics·Isabel MartinsCristina Silva Pereira
Sep 10, 2014·International Journal of Molecular Sciences·Susana CorreiaGilberto Igrejas
Dec 12, 2012·Expert Opinion on Investigational Drugs·Divya Prakash GnanadhasDipshikha Chakravortty
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Feb 14, 2013·Journal of Proteomics·Gianluca ParediAndré Martinho de Almeida
May 20, 2015·BMC Microbiology·Mette Rørbæk GantzhornLine Elnif Thomsen
Oct 15, 2013·Journal of Proteomics·Isabel MartinsCristina Silva Pereira
Feb 3, 2015·Frontiers in Microbiology·Daniel E Carey, Patrick J McNamara
Jul 3, 2021·Proteomes·Eleni I KatsarouAngeliki I Katsafadou
Aug 28, 2021·Environmental Pollution·Saurav KumarChandra Bhushan Kumar

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