Comparative Proteomics of Human and Macaque Milk Reveals Species-Specific Nutrition during Postnatal Development

Journal of Proteome Research
Kristen L BeckDanielle G Lemay

Abstract

Milk has been well established as the optimal nutrition source for infants, yet there is still much to be understood about its molecular composition. Therefore, our objective was to develop and compare comprehensive milk proteomes for human and rhesus macaques to highlight differences in neonatal nutrition. We developed a milk proteomics technique that overcomes previous technical barriers including pervasive post-translational modifications and limited sample volume. We identified 1606 and 518 proteins in human and macaque milk, respectively. During analysis of detected protein orthologs, we identified 88 differentially abundant proteins. Of these, 93% exhibited increased abundance in human milk relative to macaque and include lactoferrin, polymeric immunoglobulin receptor, alpha-1 antichymotrypsin, vitamin D-binding protein, and haptocorrin. Furthermore, proteins more abundant in human milk compared with macaque are associated with development of the gastrointestinal tract, the immune system, and the brain. Overall, our novel proteomics method reveals the first comprehensive macaque milk proteome and 524 newly identified human milk proteins. The differentially abundant proteins observed are consistent with the perspective tha...Continue Reading

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Citations

May 29, 2016·The Journal of Pediatrics·Sharon M Donovan, Bo Lönnerdal
Sep 8, 2016·The Journal of Dairy Research·Shanshan LiDaxi Ren
Oct 25, 2016·The Journal of Pediatrics·Paula MeierAnita Esquerra-Zwiers
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May 21, 2019·Journal of Pediatric Gastroenterology and Nutrition·Danielle Nicole RendinaChristopher L Coe
Feb 13, 2017·Journal of Dairy Science·Asger NissenChristine Maria Røntved
Feb 6, 2017·Proteome Science·Lina ZhangKasper Hettinga
Mar 2, 2019·Nutrients·Mohèb ElwakielKasper A Hettinga
Jan 19, 2018·Clinical Proteomics·Sadr-Ul ShaheedChris Sutton
Oct 7, 2020·Animals : an Open Access Journal From MDPI·Xueying ZhangXiangpeng Yue
Mar 16, 2021·Molecular Ecology Resources·Takumi TsutayaEnrico Cappellini
Jun 8, 2021·Frontiers in Physiology·Lindsay Sawyer
Oct 14, 2021·Database : the Journal of Biological Databases and Curation·Dan ShaoJuan Cui
Dec 28, 2021·Physiological Reports·Vaksha PatelJun Wheeler

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