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Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function

Molecular Biology and Evolution

Mar 27, 2012

Iakes EzkurdiaMichael L Tress

Abstract

Advances in high-throughput mass spectrometry are making proteomics an increasingly important tool in genome annotation projects. Peptides detected in mass spectrometry experiments can be used to validate gene models and verify the translation of putative coding sequences (CDSs). Here, ...read more

Mentioned in this Paper

Nested Transcripts
Exons
Genome
Drosophila
Protein Biosynthesis
Mass Spectrometry
Proteomics
Pseudogenes
Heterogeneous-Nuclear Ribonucleoproteins
Protein Conformation
15
106
Paper Details
References
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  • Citations38
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Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function

Molecular Biology and Evolution

Mar 27, 2012

Iakes EzkurdiaMichael L Tress

PMID: 22446687

DOI: 10.1093/molbev/mss100

Abstract

Advances in high-throughput mass spectrometry are making proteomics an increasingly important tool in genome annotation projects. Peptides detected in mass spectrometry experiments can be used to validate gene models and verify the translation of putative coding sequences (CDSs). Here, ...read more

Mentioned in this Paper

Nested Transcripts
Exons
Genome
Drosophila
Protein Biosynthesis
Mass Spectrometry
Proteomics
Pseudogenes
Heterogeneous-Nuclear Ribonucleoproteins
Protein Conformation
15
106

Similar Papers Found In These Feeds

Deep Visual Proteomics: Image-Guided Cell Characterization

Investigating human cellular proteins through a combination of highly multiplexed imaging and proteomic analyses can help characterize all human cells at the proteomic level. Discover the latest research on deep visual proteomics here.

RNA Splicing (Keystone)

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA splicing and co-transcriptional splicing in this feed.

Related Papers

Molecular Biology and Evolution

The origins, evolution, and functional potential of alternative splicing in vertebrates

Molecular Biology and EvolutionMay 10, 2011
Jonathan M MudgeJennifer Harrow
Paper Details
References
  • References89
  • Citations38
12345...
  • References89
  • Citations38
1234
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