Comparative risk of osteoporotic fracture among patients with rheumatoid arthritis receiving TNF inhibitors versus other biologics: a cohort study.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A ShinEun Ha Kang

Abstract

In this population-based cohort study on comparative osteoporotic fracture risks between different biologic disease-modifying drugs among patients with rheumatoid arthritis (RA), we did not find a significant difference in the risk of osteoporotic fractures between RA patients receiving TNF inhibitors versus abatacept or tocilizumab. We aimed to investigate the comparative risk of osteoporotic fractures between rheumatoid arthritis (RA) patients who initiated TNF inhibitors (TNFis) versus abatacept or tocilizumab. Using the Korea National Health Insurance Service datasets from 2002 to 2016, RA patients who initiated TNFis, abatacept, or tocilizumab were identified. The primary outcome was a composite end point of non-vertebral fractures and hospitalized vertebral fractures; secondary outcomes were two components of the primary outcome and fractures occurring at the humerus/forearm. Propensity score (PS) matching with a variable ratio up to 10 TNFi initiators per 1 comparator drug initiator was used to adjust for > 50 baseline confounders. We estimated hazard ratios (HRs) and 95% confidence interval (CI) of fractures comparing TNFi initiators to abatacept and to tocilizumab by Cox proportional hazard models stratified by a match...Continue Reading

References

Jul 1, 1992·Journal of Clinical Epidemiology·W A RayM L Adams
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B A SchevenS A Duursma
Dec 25, 2004·Journal of Clinical Epidemiology·Vijaya SundararajanWilliam A Ghali
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Seung Hun LeeNam H Cho
Aug 29, 2009·Arthritis and Rheumatism·Roland AxmannGeorg Schett
Aug 5, 2010·Arthritis Research & Therapy·Seo Young KimDaniel H Solomon
Feb 25, 2011·Arthritis Research & Therapy·Seo Young KimDaniel H Solomon
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Jan 26, 2013·Journal of Clinical Epidemiology·Marie HudsonSonia Jean
Aug 13, 2013·Seminars in Arthritis and Rheumatism·Anne C Bay-JensenMorten A Karsdal
Nov 28, 2013·Current Opinion in Rheumatology·Arnd Kleyer, Georg Schett
Apr 24, 2014·Arthritis & Rheumatology·Susanne Roser-PageM Neale Weitzmann
Mar 25, 2015·Nature Reviews. Rheumatology·Kazuki YoshidaSeoyoung C Kim
Nov 12, 2015·RMD Open·Maria Manara, Luigi Sinigaglia
Jan 1, 2019·Annals of Internal Medicine·Michael FralickElisabetta Patorno
May 9, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroyuki OkadaSakae Tanaka

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Citations

Mar 3, 2021·Current Opinion in Rheumatology·Katherine D WyshamDolores M Shoback

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