Comparative RNA-seq analysis of the Tritrichomonas foetus PIG30/1 isolate from pigs reveals close association with Tritrichomonas foetus BP-4 isolate 'bovine genotype'

Veterinary Parasitology
Victoria Morin-AdelineJan Šlapeta

Abstract

Tritrichomonas foetus was described as a commensal of the stomach, caecum and nasal cavity of pigs before it was recognised as the cause of reproductive tract disease of cattle. T. foetus also causes chronic large bowel diarrhoea in domestic cats. Multi-locus genotyping and comparative transcriptome analysis has previously revealed that T. foetus isolated from cat and cattle hosts are genetically distinct, referred to as the 'feline genotype' and 'bovine genotype', respectively. Conversely, multi-locus genotyping has grouped porcine T. foetus with the 'bovine genotype'. To compare the extent of the similarity between porcine T. foetus and cattle 'bovine genotype' isolates, RNA-sequencing (RNA-seq) was used to produce the first cell-wide transcriptome library of porcine T. foetus PIG30/1. Comparative transcriptome analysis of the PIG30/1 with the published bovine (BP-4) and feline (G10/1) transcriptomes revealed that the porcine T. foetus shares a 4.7 fold greater number of orthologous genes with the bovine T. foetus than with the feline T. foetus. Comparing transcription of the virulence factors, cysteine proteases (CP) between the three isolates, the porcine T. foetus was found to preferentially transcribe CP8 like the 'bovine...Continue Reading

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Citations

Dec 15, 2015·Parasitology·Victoria Morin-Adeline, Jan Šlapeta
Jun 18, 2016·Trends in Parasitology·Joel BarrattJohn Ellis
Sep 10, 2016·Parasitology·Andrea CasterianoJan Šlapeta
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Nov 25, 2017·BMC Veterinary Research·Yuanyuan ShiYafeng Qiu
Sep 11, 2020·BMC Complementary Medicine and Therapies·Mendel FriedmanKirkwood M Land

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