Abstract
To evaluate the role of complement in pneumococcal and staphylococcal pneumonia, we decomplemented rats with cobra venom factor and inoculated them intratracheally with Staphylococcus aureus or type 25 pneumococci. S. aureus produced a patchy bronchopneumonia in normal Sprague-Dawley or Lewis rats, and decomplementation did not increase the severity of staphylococcal infection in either rat strain as judged by quantitative cultures of the lungs and blood at 6, 24, and 48 h after inoculation. In contrast, decomplementation markedly increased the severity of pneumonia caused by type 25 pneumococci in Sprague-Dawley and Lewis rats. In Sprague-Dawley rats, decomplementation significantly increased the number of bacteria in the lungs at 3, 6, and 24 h of infection. Bacteremia developed early in decomplemented Sprague-Dawley rats, but the higher pulmonary bacterial counts did not appear to be caused by bacteremic seeding of the lungs. Decomplemented Sprague-Dawley rats inoculated intravenously with pneumococci failed to develop the very high levels of bacteria in the lungs that were observed when the rats were inoculated intratracheally. Moreover, decomplemented Lewis rats inoculated intratracheally with pneumococci developed signifi...Continue Reading
References
Aug 1, 1976·Infection and Immunity·G J Jakab
Jul 1, 1977·Infection and Immunity·M J AnsfieldW G Johanson
Aug 1, 1978·The Journal of Clinical Investigation·G N GrossA K Pierce
Jan 1, 1979·Journal of Immunological Methods·J D Coonrod, S D Jenkins
May 1, 1978·Infection and Immunity·R F Berendt
Jun 1, 1979·The Journal of Experimental Medicine·A B van oud Alblas, R van Furth
Jul 1, 1979·Infection and Immunity·S R RehmA K Pierce
Jul 1, 1979·Infection and Immunity·I A Bakker-WoudenbergM F Michel
Aug 1, 1976·The Journal of Clinical Investigation·J A JuersW W Cook
Aug 1, 1980·The Journal of Clinical Investigation·S R RehmA K Pierce
Aug 1, 1980·The Journal of Infectious Diseases·J C GuckianD P Fine
Aug 1, 1981·Infection and Immunity·J D Coonrod
Apr 1, 1982·Infection and Immunity·S R Rehm, J D Coonrod
Mar 1, 1981·Reviews of Infectious Diseases·J D Coonrod, K Yoneda
Jan 1, 1980·Lung·G D HarrisW G Johanson
Citations
Jun 1, 1990·Antonie van Leeuwenhoek·J E van DamH Snippe
May 7, 2020·American Journal of Respiratory and Critical Care Medicine·William BainJanet S Lee
Jan 1, 1984·Critical Reviews in Microbiology·J A Winkelstein
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·C S Witt, M P Alpers
Nov 12, 2002·Environmental Health Perspectives·Judith T ZelikoffRichard B Schlesinger
Jan 1, 1989·Pediatric Pulmonology·J L SotomayorR W Wilmott
Jul 25, 2009·Journal of Medicinal Food·S M SayedAhmed Abd El Fattah Aamer
May 25, 1999·Infection and Immunity·R B AlcantaraM J Gentry
Nov 1, 1987·Infection and Immunity·D Frederick, E L Pesanti
Sep 1, 1983·Infection and Immunity·M C CerquettiJ A Bellanti
Mar 1, 1984·Infection and Immunity·J C PatonA Ferrante
Feb 1, 1986·Microbial Pathogenesis·E TuomanenA Tomasz