Comparative safety and effectiveness of cognitive enhancers for Alzheimer's dementia: protocol for a systematic review and individual patient data network meta-analysis

BMJ Open
Areti Angeliki VeronikiAndrea C Tricco

Abstract

Alzheimer's dementia (AD) is the most common cause of dementia, and several organisations, such as the National Institute for Health and Care Excellence, suggest that management of patients with AD should be tailored to their needs. To date, little research has been conducted on the treatment effect in different subgroups of patients with AD. The aim of this study is to examine the comparative effectiveness and safety of cognitive enhancers for different patient characteristics. We will update our previous literature search from January 2015 forward, using the same terms and electronic databases (eg, MEDLINE) from our previous review. We will additionally search grey literature and scan the reference lists of the included studies. Randomised clinical trials of any duration conducted at any time comparing cognitive enhancers alone or in any combination against other cognitive enhancers, or placebo in adults with AD will be eligible. The outcomes of interest are cognition according to the Mini-Mental State Examination, and overall serious adverse events. For each outcome and treatment comparison, we will perform a Bayesian hierarchical random-effects meta-analysis combining the individual patient data (IPD) from each eligible stu...Continue Reading

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Citations

Mar 17, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Guillermo Prada-RamallalAdolfo Figueiras
May 28, 2019·Statistics in Medicine·Loukia M SpineliKonstantinos Pateras
Jun 7, 2017·Research Synthesis Methods·Dan JacksonRose Baker
Jun 4, 2019·Journal of Clinical Epidemiology·Areti Angeliki VeronikiAndrea C Tricco

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