Abstract
Culture-based diagnosis of candidaemia suffers poor sensitivity and prolonged turnaround time. The 1,3-beta-D-glucan (BDG) assay is a non-culture-based broad fungal antigen with rapid turnaround time. To assess overall, species-specific and population-specific sensitivity of the BDG assay for candidaemia, to determine if the BDG assay is able to detect candidaemia prior to blood culture collection, and to evaluate the performance of the assay for the detection of Candida auris candidaemia. A retrospective review of all blood cultures (BC) with C albicans, C parapsilosis, C glabrata, C krusei and C auris was performed. A corresponding BDG result (Fungitell® ) within 10 days of the BC was sought on the laboratory information system. Overall sensitivity of the assay was 79% (95% CI 73-85; 173/218). Per species sensitivity was 81% (95% CI 72-90; 66/81) for C albicans, 72% (61-83; 60/83) for C parapsilosis, 90% (95% CI 79-100; 27/30) for C glabrata, 71% (95% CI 43-99; 10/14) C auris and 100% (10/10) for C krusei. No statistically significant difference in sensitivity between species was noted (P = .093). The assay demonstrated 92% (59/64) sensitivity in neonatal ICU (P = .047) compared to 94% (15/16) in surgery, 81% (59/73) in adult...Continue Reading
References
Nov 30, 2006·Antimicrobial Agents and Chemotherapy·Jeniel NettDavid Andes
Jan 24, 2009·Microbiology and Immunology·Kazuo SatohHideyo Yamaguchi
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J AcostaA del Palacio
Oct 22, 2011·International Journal of Molecular Sciences·Maria Teresa MontagnaGiuseppina Caggiano
Jan 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Jun 21, 2013·American Journal of Respiratory and Critical Care Medicine·Frederic TissotUNKNOWN Fungal Infection Network of Switzerland (FUNGINOS)
Jul 2, 2014·Clinical Microbiology Reviews·Marios ArvanitisEleftherios Mylonakis
Aug 2, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Song HeFang-Hong Gong
Oct 9, 2015·The New England Journal of Medicine·Bart Jan Kullberg, Maiken C Arendrup
Apr 30, 2016·The Journal of Antimicrobial Chemotherapy·Nelesh P GovenderUNKNOWN TRAC-South Africa group
Aug 22, 2016·BMC Infectious Diseases·Henrique Marconi Sampaio PinhatiArnaldo Lopes Colombo
Jan 20, 2017·Mycoses·Rindidzani E MagoboUNKNOWN TRAC-South Africa group
Apr 4, 2017·Medical Mycology·Marjorie CornuBoualem Sendid
Nov 18, 2017·Jornal de pediatria·Abd Elazeez ShabaanBasma Shouman
Jan 6, 2018·The Journal of Antimicrobial Chemotherapy·Frederic LamothThierry Calandra
Apr 15, 2018·Mycoses·Alba Ruiz-GaitánJavier Pemán
Feb 13, 2019·The Journal of Antimicrobial Chemotherapy·Ashutosh SinghAnuradha Chowdhary
Citations
Nov 8, 2020·BMC Infectious Diseases·Li ZhongGensheng Zhang
Nov 13, 2020·BMC Infectious Diseases·Jingjing ChenHong Shang
Feb 20, 2021·International Journal of Nanomedicine·Shan HuYing Yang
Jun 11, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Joveria FarooqiKauser Jabeen
Jun 29, 2021·Current Fungal Infection Reports·C KeighleyS C-A Chen