Comparative sensitivity of harbour and grey seals to several environmental contaminants using in vitro exposure

Marine Pollution Bulletin
M M DufresneMichel Fournier

Abstract

In this study, we investigated the effects of cadmium chloride (CdCl(2)), mercury chloride (HgCl(2)), methylmercury chloride (CH(3)HgCl), and PCBs on lymphocyte proliferation in phocids. PBMCs isolated from harbour and grey seals were exposed in vitro to varying concentrations of contaminants. A reduction of viability occurred when cells were exposed to 10(-4)M HgCl(2) or CH(3)HgCl or to 50ppm of Aroclor 1254. In both grey and harbour seals, T-lymphocyte proliferation was suppressed when their cells were incubated with 5 x 10(-5)M CdCl(2) or 10(-4)M HgCl(2). An inhibition of proliferation occurred with CH(3)HgCl from 10(-6)M in grey seals and from 10(-5)M in harbour seals. In grey seals, Aroclor 1254 reduced lymphocyte proliferation at 15ppm. In both harbour and grey seals, CH(3)HgCl was ten times more immunotoxic that HgCl(2). From IC(50), chemicals were ranked in terms of toxicity as followed: CH(3)HgCl>CdCl(2)>HgCl(2)>Aroclor 1254.

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Citations

Aug 13, 2015·Archives of Environmental Contamination and Toxicology·Aurélie DupontKrishna Das
Jul 5, 2015·Archives of Environmental Contamination and Toxicology·Andrea BogomolniSylvain De Guise
Nov 23, 2015·Environment International·Jean-Pierre W DesforgesRune Dietz
Jul 5, 2011·Marine Pollution Bulletin·Antje KakuschkeAndreas Prange
May 21, 2016·Marine Pollution Bulletin·Krishna DasUrsula Siebert
Sep 7, 2017·Environmental Science & Technology·Jean-Pierre DesforgesRune Dietz

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