PMID: 7527088Jan 1, 1995Paper

Comparative sequence analysis of the reovirus S4 genes from 13 serotype 1 and serotype 3 field isolates

Journal of Virology
R KedlL A Schiff

Abstract

The reovirus sigma 3 protein is a major outer capsid protein that may function to regulate translation within infected cells. To facilitate the understanding of sigma 3 structure and functions and the evolution of mammalian reoviruses, we sequenced cDNA copies of the S4 genes from 10 serotype 3 and 3 serotype 1 reovirus field isolates and compared these sequences with sequences of prototypic strains of the three reovirus serotypes. We found that the sigma 3 proteins are highly conserved: the two longest conserved regions contain motifs proposed to function in binding zinc and double-stranded RNA. We used the 16 viral isolates to investigate the hypothesis that structural interactions between sigma 3 and the cell attachment protein, sigma 1, constrain their evolution and to identify a determinant within sigma 3 that is in close proximity to the sigma 1 hemagglutination site.

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Citations

Jun 20, 2001·Journal of Virology·M Mochow-Grundy, T S Dermody
Sep 15, 2006·Virus Genes·Jieyuan JiangKevin M Coombs
Jan 19, 2012·The Journal of Biological Chemistry·Joshua D DoyleTerence S Dermody
May 3, 2002·The Journal of Biological Chemistry·Daniel H EbertTerence S Dermody
Jul 5, 2002·Journal of Virology·Joseph W GoldenLeslie A Schiff
Jan 13, 2012·Journal of Virology·Anthony J SnyderSuchetana Mukhopadhyay
May 21, 2015·MBio·Athmaram Thimmasandra NarayanappaSubbiah Elankumaran
Dec 13, 2003·The Journal of Biological Chemistry·Joseph W GoldenLeslie A Schiff
Jan 28, 2006·Journal of Virology·Jennifer A SmithLeslie A Schiff
Feb 14, 2007·Veterinary Research·Canio Buonavoglia, Vito Martella
Oct 1, 1996·Journal of Virology·M L NibertK M Coombs

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