PMID: 8592801Nov 1, 1995Paper

Comparative severity of respiratory lesions of sialodacryoadenitis virus and Sendai virus infections in LEW and F344 rats

Veterinary Pathology
S C LiangJ R Lindsey

Abstract

In several chronic diseases, lesions are more severe in LEW rats than in F344 rats. To determine whether or not acute viral diseases also are more severe in LEW rats than in F344 rats, we inoculated 6-7-week-old LEW and F344 rats with 10(7.2) cell culture infective units of sialodacryoadenitis virus or 10(4.7) infective units of Sendai virus. Twenty-four rats of each strain were given each virus. Lesions in nasal passages, tracheas, intrapulmonary airways, and pulmonary alveoli in 6 or 12 rats inoculated with each virus were assessed by scoring 5, 10, and 14 days after inoculation. Both viruses caused typical patchy necrotizing rhinitis, tracheitis, bronchitis, and bronchiolitis, with multifocal pneumonitis, in rats of both strains. Mean lesion indices for LEW rats given sialodacryoadenitis virus were significantly different from those for F344 rats for nasal passages on days 10 (0.999 vs. 0.680) and 14 (0.736 vs. 0.278), bronchi on day 5 (0.479 vs. 0.361), and alveoli on day 5 (0.677 vs. 0.275). Lesion indices for LEW rats given Sendai virus were significantly different from those for F344 rats for nasal passages on days 10 (1.000 vs. 0.611) and 14 (0.778 vs. 0.583); trachea on day 10 (0.625 vs. 0.028); bronchi on days 5 (0.47...Continue Reading

References

Jan 1, 1978·Canadian Journal of Microbiology·R B Stewart, M J Tucker
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May 1, 1986·Veterinary Pathology·Z W Wojcinski, D H Percy
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Citations

Sep 10, 2003·American Journal of Respiratory Cell and Molecular Biology·Judy M Hickman-DavisSadis Matalon
Feb 28, 2001·The Veterinary Clinics of North America. Small Animal Practice·G P LanganC L Wardrip
Sep 26, 2013·The Journal of Veterinary Medical Science·Atsushi AsanoTakashi Agui
Oct 10, 2013·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·J AarthiS Sujatha
May 28, 2017·Virology Journal·Xing-Yi GeYun-Zhi Zhang
Dec 17, 2020·Animals : an Open Access Journal From MDPI·Valentina ZappulliMassimo Castagnaro

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