PMID: 8583018Aug 1, 1995Paper

Comparative staining in vitro and plaque inhibitory properties in vivo of 0.12% and 0.2% chlorhexidine mouthrinses

Journal of Clinical Periodontology
R G SmithR Newcombe

Abstract

The mere incorporation of an active ingredient in an oral hygiene product does not necessarily guarantee efficacy. As new formulations appear, it would seem prudent to at least screen for activity by comparison with an established product. The aim of this study was to compare a new 0.12% chlorhexidine containing rinse with a well researched 0.2% chlorhexidine rinse product. The rinses were firstly compared in vitro for dietary staining effects and in vivo for plaque inhibition. Both formulations in vitro produced progressive staining of acrylic specimens with increasing passages through a standard tea solution. The clinical investigation was a 3-treatment, randomised, double blind, crossover, 4-day plaque regrowth study, balanced for 1st and 2nd order residual effects and involving 24 volunteers. From a zero plaque baseline, volunteers suspended oral hygiene and rinsed 2 x per day with the allocated rinse. The chlorhexidine doses were 18 mg and 20 mg per rinse for the 0.12% and 0.2% formulations, respectively. Plaque was scored by area and index on day 5. The results showed that the 2 chlorhexidine rinses were similar in efficacy by comparison with the control rinse. These studies in vitro and in vivo indicate that the chlorhex...Continue Reading

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Citations

Jan 24, 2004·Journal of Dentistry·Andrew Joiner, Gopal Thakker
Apr 2, 2003·Journal of Periodontology·Jan A M KeijserFridus A Van der Weijden
Apr 7, 2005·Journal of Clinical Periodontology·Marc QuirynenDaniel van Steenberghe
Apr 26, 2006·Journal of Clinical Periodontology·Nicole B ArweilerThorsten M Auschill
Mar 2, 2011·International Journal of Dental Hygiene·P KalyanaS Sweta
Apr 8, 2016·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Susanthi RonankiPadma Reddy
Nov 19, 2010·Journal of Applied Oral Science : Revista FOB·Fabrício Batistin ZanattaCassiano Kuchenbecker Rösing
Dec 18, 2008·Journal of Applied Oral Science : Revista FOB·Andresa Piacezzi NascimentoIzabel Yoko Ito
Apr 22, 2009·American Journal of Rhinology & Allergy·Achim BeulePeter-John Wormald
Aug 16, 2008·American Journal of Rhinology·Rowan ValentinePeter-John Wormald
Feb 3, 2006·International Journal of Dental Hygiene·M AddyJ Moran
May 3, 2002·Journal of Veterinary Dentistry·Philippe Hennet

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