PMID: 6983890Nov 23, 1982Paper

Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1

Biochemistry
M S KrangelJ L Strominger

Abstract

Comparative primary structural analyses have begun to elucidate polymorphic residues and segments of the class I antigens of the major histocompatibility complex, at least some of which presumably contribute to determinants important in immune recognition events. HLA-A2 structural variants have been described which are serologically indistinguishable from other HLA-A2 antigens, yet which can be recognized neither by HLA-A2 specific alloimmune nor by HLA-A2 restricted, virus immune cytotoxic T lymphocytes. This study utilizes double-label tryptic peptide comparisons in combination with both conventional and microsequence analyses to investigate the structure of two such variants, M7 and DR1. We find that these variants are identical with each other and differ from the predominant HLA-A2 heavy chain species by a glutamine to arginine substitution at residue 43, by an unidentified substitution in the tryptic peptide spanning residues 147-157, and by an as yet poorly defined alteration in glycosylation. Structural information from these and other variants should be useful in precisely defining functionally important determinants on the molecule.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H T OrrJ L Strominger
Dec 1, 1979·Cell·M S KrangelJ L Strominger
Apr 7, 1977·Nature·E GoulmyJ J van Rood
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C TerhorstJ L Strominger
May 1, 1980·The Journal of Experimental Medicine·C J MeliefH I Kohn
Jun 1, 1980·The Journal of Experimental Medicine·L A Sherman
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J A López de CastroH T Orr
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G A EvansJ G Seidman
Jan 1, 1980·Annual Review of Genetics·R NairnS G Nathenson
Jan 1, 1982·Immunogenetics·R W MelvoldG R Dunn

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Citations

Jan 1, 1983·Immunogenetics·V H Engelhard, C Benjamin
Jan 1, 1988·Immunogenetics·R CastañoJ A López de Castro
Jan 1, 1985·Immunogenetics·A K SoodS M Weissman
Jul 1, 1986·Human Immunology·J J van der PoelJ J van Rood
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A HermanV H Engelhard
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C S ReissS J Burakoff
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A VegaJ A López de Castro
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H AllenR Flavell
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J McMichaelJ L Strominger
Dec 1, 1985·The Journal of Experimental Medicine·B T SpearD B Wilson
Dec 1, 1995·The Journal of Experimental Medicine·D BarouchH G Rammensee
Jan 1, 1984·Immunogenetics·E GoulmyJ J van Rood
Jul 1, 1985·Immunological Reviews·J A Lopez de CastroJ L Strominger
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·D G CampbellR W Baldwin
Jun 14, 2005·Molecular Immunology·Lenong Li, Marlene Bouvier
Apr 20, 2018·The FEBS Journal·Peter Parham
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·David J TophamAndrea Sant

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