PMID: 16521537Mar 9, 2006Paper

Comparative structural analysis of myosin light chains and gene duplication in fish

Izvestiia Akademii nauk. Seriia biologicheskaia
N S Miuge, N D Ozerniuk

Abstract

Origin and structure of myosin light chain (MLC) proteins have been studied by comparative analysis of fish mlc1, mlc2, and mlc3 genes encoding MLC1, MLC2, and MLC3, respectively. The exon-intron structure of these genes has been analyzed in zebrafish Danio rerio, loach Misgurnus fossilis, fugu Takifugu rubripes, and Nile puffer Tetraodon fahaka. We propose that mlc1 and mlc3 are homologues genes originated by fish-specific whole genome duplication (paralogs). This is supported by high sequence similarity between mlc1 and mlc3 as well as by the exon-intron structure of these genes and their localization on different chromosomes. Exons 2 to 5 of mlc1 and mlc3 are highly conserved and have similar splicing sites. A paralog gene of mlc2 resulting from a similar duplication event has been identified in zebrafish genome. Expression of mlc2 paralog is limited to the larval stages of Danio rerio and to regenerating tissues of the adult fish. There is a possibility that the paralog of mlc2 encodes larval myosin light chain protein (larval MLC) previously reported in a number of fish species.

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C E Rozek, N Davidson
Nov 14, 1971·Journal of Molecular Biology·A G Weeds, S Lowey
May 15, 1974·European Journal of Biochemistry·G Frank, A G Weeds
Apr 1, 1984·Developmental Biology·G S Butler-Browne, R G Whalen
Mar 1, 1983·The Journal of Cell Biology·M T CrowF E Stockdale
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Oct 16, 1999·Nature·C H Cheng, L Chen
Dec 22, 1999·Seminars in Cell & Developmental Biology·S Ohno
Nov 10, 2000·Science·M Lynch, J S Conery
May 2, 2001·Nature Reviews. Genetics·K H Wolfe
Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J S TaylorA Meyer
Nov 3, 2001·Genome Research·R Friedman, A L Hughes
Jan 10, 2002·Genome Research·Xun Gu, Wei Huang
Feb 2, 2002·Nature Reviews. Genetics·Rhea Vallente Samonte, Evan E Eichler
Mar 6, 2003·Genome Research·John S TaylorYves Van de Peer
Apr 10, 2003·Trends in Genetics : TIG·Wei-Ping YuByrappa Venkatesh

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