Comparative structural analysis of the binding domain of follicle stimulating hormone receptor.

Proteins
Qing R Fan, Wayne A Hendrickson

Abstract

Proteins with leucine-rich repeats (LRRs) specialize in mediating protein-protein interactions. The hormone binding portion of the receptor for follicle stimulating hormone (FSH) is an LRR protein by sequence, and the crystal structure of this domain from human FSH receptor in a complex with FSH shows that it does indeed have an LRR structure. It differs from other LRR domains, however, in being an all-beta protein composed of highly irregular repeats and having only slight overall curvature. Despite these distinctions and a superficial resemblance to beta-helical proteins, the binding domain of FSH receptor clearly is an LRR protein. The structure does consist of two parts with distinctively different curvatures. Comparison with the structures of other LRR-containing proteins shows a correlation between curvature and main-chain hydrogen bonding pattern of the parallel beta-sheet. The hormone-binding site is located at the concave surface of the receptor structure, a feature common to proteins with LRR motifs. Analysis of the ligand-binding site of LRR-containing proteins reveals that they generally utilize extensive interface area and a large number of charged residues to facilitate high-affinity protein-protein interactions.

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Feb 14, 1971·Journal of Molecular Biology·B Lee, F M Richards
Jan 1, 1981·Annual Review of Biochemistry·J G Pierce, T F Parsons
Jun 1, 1995·Current Opinion in Structural Biology·B Kobe, J Deisenhofer
Dec 20, 1993·Journal of Molecular Biology·M C Lawrence, P M Colman
Feb 2, 1999·Journal of Molecular Biology·L Lo ConteJ Janin
Dec 19, 2001·Progress in Biophysics and Molecular Biology·J Jenkins, R Pickersgill
Dec 26, 2001·Current Opinion in Structural Biology·B Kobe, A V Kajava
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·P BradleyB Berger
Mar 20, 2002·Vitamins and Hormones·James A DiasAnja Schmidt
Jul 4, 2003·The EMBO Journal·William A BartonDimitar B Nikolov
Aug 30, 2003·Trends in Endocrinology and Metabolism : TEM·Sheau Yu Teddy Hsu
Jan 30, 2004·Proteins·Purevjav EnkhbayarNorio Matsushima
Jul 1, 1996·Acta Crystallographica. Section D, Biological Crystallography·G J Kleywegt
Jan 22, 2005·Nature·Qing R Fan, Wayne A Hendrickson
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Jane SandersBernard Rees Smith
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cecile MorlotAndrew A McCarthy

❮ Previous
Next ❯

Citations

Apr 29, 2011·The Journal of Biological Chemistry·Gunnar KleinauGerd Krause
Feb 22, 2012·Molecular and Cellular Endocrinology·K M J Menon, Bindu Menon
Oct 24, 2013·The Journal of Obstetrics and Gynaecology Research·Xiaoyan ZhangCongjian Xu
Apr 13, 2011·Pain·Frances V Abbott
Jul 9, 2016·Molecular Endocrinology·Gunnar KleinauAnnette Grüters-Kieslich
May 7, 2013·Endocrine Reviews·Gunnar KleinauHeike Biebermann
May 3, 2021·International Journal of Biological Macromolecules·Divya MishraManish Tiwari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.