PMID: 9649615Jul 3, 1998Paper

Comparative structure analysis of vertebrate ribonuclease P RNA

Nucleic Acids Research
C PitulleNorman R Pace

Abstract

Ribonuclease P cleaves 5'-precursor sequences from pre-tRNAs. All cellular RNase P holoenzymes contain homologous RNA elements; the eucaryal RNase P RNA, in contrast to the bacterial RNA, is catalytically inactive in the absence of the protein component(s). To understand the function of eucaryal RNase P RNA, knowledge of its structure is needed. Considerable effort has been devoted to comparative studies of the structure of this RNA from diverse organisms, including eucaryotes, primarily fungi, but also a limited set of vertebrates. The substantial differences in the sequences and structures of the vertebrate RNAs from those of other organisms have made it difficult to align the vertebrate sequences, thus limiting comparative studies. To expand our understanding of the structure of diverse RNase P RNAs, we have isolated by PCR and sequenced 13 partial RNase P RNA genes from 11 additional vertebrate taxa representing most extant major vertebrate lineages. Based on a recently proposed structure of the core elements of RNase P RNA, we aligned the sequences and propose a minimum consensus secondary structure for the vertebrate RNase P RNA.

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Citations

Mar 10, 2001·Journal of Cellular Physiology·S XiaoD R Engelke
Apr 21, 2004·Journal of Molecular Biology·Mirela AndronescuAnne Condon
Jan 19, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Athanasius F BompfünewererChristina Witwer
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May 20, 2006·Bioinformatics·Anke Busch, Rolf Backofen
Apr 23, 2013·Journal of Bioinformatics and Computational Biology·Juan Antonio Garcia-MartinIvan Dotu
Jun 5, 2002·Annual Review of Biochemistry·Shaohua XiaoDavid R Engelke
Apr 7, 2005·RNA·Steven M MarquezNorman R Pace
May 10, 2013·Annual Review of Biophysics·Alfonso Mondragón
Apr 7, 2005·Archaea : an International Microbiological Journal·Thomas A Hall, James W Brown
Apr 6, 2006·Critical Reviews in Biochemistry and Molecular Biology·Scott C Walker, David R Engelke
Jul 28, 2004·Journal of Molecular Biology·Scott C Walker, Johanna M Avis
Oct 3, 2003·Chembiochem : a European Journal of Chemical Biology·Heike GruegelsiepeRoland K Hartmann
May 20, 2011·Chemistry : a European Journal·Tuomas Lönnberg
Nov 4, 2006·Molecular Cell·Steven M MarquezNorman R Pace
Aug 10, 2010·Cell·Geng WangMichael A Teitell

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