Comparative studies of (--)-, (+/-)-propranolol, atenolol, guanethidine, bretylium and tetracaine on adrenergic transmission

British Journal of Pharmacology
M KaihoY Misu

Abstract

1 Effects of (--)-, (+/-)-, and (+)-propranolol, atenolol, guanethidine, bretylium and tetracaine were studied on relaxation responses of rabbit ileum and contractile responses of rabbit pulmonary artery and guinea-pig vas deferens to electrical nerve stimulation (2 to 50 Hz). 2 In the ileum, inhibition by tetracaine 3.3 x 10(-6) M occurred at high frequencies of stimulation, while bretylium 1.2 x 10(-4) M and guanethidine 2 x 10(-5) M inhibited responses at all frequencies, the latter producing greater inhibition at low frequencies. 3 (+/-)-Propranolol 10(-5) M produced a tetracaine-type inhibition after 1 h and a bretylium-pattern after 2 h in the ilea and pulmonary arteries and a transition from bretylium- to guanethidine-pattern in the vas deferens, while atenolol 2 x 10(-5) to 10(-4) M produced guanethidine-type inhibition in all preparations. 4 (--)-, (+/-)-, and (+)-Propranolol 3 x 10(-6) to 3.3 x 10(-5) M were equipotent in the vas deferens and ileum. However, inhibition by (--)-propranolol 3.3 x 10(-5) M persisted in the ileum, while that by the (+)-isomer was partially restored by washing. 5 (--)- or (+)-Propranolol 3.3 x 10(-5) M or atenolol 2 x 10(-5) M did not inhibit relaxation of the ileum after the bath temperat...Continue Reading

References

Mar 1, 1976·The Journal of Pharmacy and Pharmacology·I E Hughes, B Kneen
Dec 1, 1976·Drugs·H J Waal-Manning
May 1, 1978·British Journal of Pharmacology·Y Misu, H Nishio
Mar 1, 1973·The Journal of Pharmacy and Pharmacology·E J Mylecharane, C Raper
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·K H RahnG Planz
Dec 1, 1968·The Journal of Pharmacy and Pharmacology·M D DAYP R Warren
Nov 1, 1970·The Journal of Pharmacy and Pharmacology·A M Barrett, B Nunn
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Apr 1, 1974·Japanese Journal of Pharmacology·T Kubo, Y Misu
Aug 1, 1972·British Journal of Pharmacology·S Eliash, M Weinstock
Jul 1, 1971·British Journal of Pharmacology·O D Gulati, S Jaykar
Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·S HUKOVIC
Jan 1, 1965·Annual Review of Pharmacology·A L BOURA, A F GREEN
Sep 18, 1930·The Journal of Physiology·B Finkleman

Citations

May 1, 1986·International Ophthalmology·H A Fleig, G K Krieglstein
Jan 22, 1982·European Journal of Pharmacology·Y MisuT Kubo
Dec 1, 1983·British Journal of Clinical Pharmacology·G A HurwitzT E Gaffney
Jul 1, 1984·Medicinal Research Reviews·M Simonyi
Apr 1, 1986·Medicinal Research Reviews·Y Misu, T Kubo

Related Concepts

Metazoa
Tenormin
Bretylium Compounds
Ornid
Guanethidine Sulfate (2: 1), 14C-Labeled
Cavia porcellus
Ileum
Synaptic Transmission
Propanolamines
Rexigen

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