PMID: 6991642Jan 1, 1980Paper

Comparative studies of five strains of mumps virus in vitro and in neonatal hamsters: evaluation of growth, cytopathogenicity, and neurovirulence

Journal of Medical Virology
M McCarthyR T Johnson

Abstract

The growth and cytopathogenicity of five strains of mumps virus were examined in six types of cell cultures and in neonatal hamsters. These strains included the MJ and RW strains, both recent cerebrospinal fluid isolates: the neuroadapted Kilham strain; the Enders strain adapted to chick embryo; and the Jeryl Lynn vaccine strain adapted to chick cell culture. The MJ, RW, and Kilham strains all produced infectious virus without restriction in vitro, but the RW strain did not cause obvious cytopathic effect; the MJ and Kilham strains were cytopathic. The Enders and Jeryl Lynn strains adapted to chick embryo cells were cytopathic and productive in chick cell culture but were restricted in ability to grow productively in vitro on mammalian cell types, even failing to produce noninfectious particles in some cases. In vitro cytopathogenicity was a host-independent property of a specific virus strain, but the type of cytopathic effect manifest in culture (eg, fusion, cytoplasmic vacuoles) depended on both the strain and the host cell. The ability of a virus strain to invade the brain parenchyma and infect neurons in vivo appeared to correlate with the strain's cytopathogenicity and not with passage history or adaptive status.

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Citations

Dec 26, 2008·AIDS Research and Human Retroviruses·Raphael LwembeHiroshi Ichimura
Oct 1, 1993·Neuropathology and Applied Neurobiology·S KelićK Kristensson
Mar 16, 2005·Journal of Virology·Toru KubotaAtsushi Kato
Jan 28, 2006·Journal of Virology·Rebecca L WilsonBiao He
Nov 1, 1992·Virology·C Di Simone, J D Baldeschwieler
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Sep 18, 2014·The Journal of Pathology·Steven RubinW Paul Duprex
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Feb 15, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Elizabeth Kelly, Stephen J Russell
Dec 19, 2001·Journal of Medical Virology·Shizuko SaikaKazuyoshi Suzuki
Jul 9, 1999·Reviews in Medical Virology·E G Brown, K E Wright
Jul 13, 2002·Journal of Medical Virology·John Furesz
Apr 6, 2021·Frontiers in Immunology·Han WuDaishu Han
Jun 1, 1985·Journal of Virology·F Gonzalez-ScaranoN Nathanson
May 1, 1993·Journal of Virology·K TanabayashiA Yamada

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