Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses

FEBS Letters
S V SereginS N Shchelkunov

Abstract

To study specific properties of the human gamma-interferon (gamma-IFN) receptor-like proteins of the highly virulent and low virulent strains of variola (smallpox) virus (VAR) recombinant plasmids determining synthesis of these proteins in E. coli cells have been constructed. The recombinant viral gamma-IFN receptor-like proteins have been found to have high interferon-neutralising activity with regard to human gamma-IFN but not murine gamma-IFN and human alpha-IFN. The variola major and variola minor proteins under study do not differ in the efficiency of human gamma-IFN antiviral activity inhibition.

Citations

Jan 19, 2007·Journal of Virology·Isaac G SakalaGunasegaran Karupiah
Apr 14, 2011·Molekuliarnaia biologiia·S N Shchelkunov
Mar 6, 2012·BMC Genomics·Akira R KinjoDaron M Standley
Oct 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Grant McFadden
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathleen H RubinsDavid A Relman
Aug 18, 2012·Advances in Virology·Sergei N Shchelkunov
Feb 7, 2006·Lancet·Zack S MooreJ Michael Lane
Jun 27, 2002·Virology·S N ShchelkunovB Moss
Jan 20, 2000·Virology·S N ShchelkunovJ J Esposito

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