Comparative studies of latex extracts used in skin testing

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J N FinkV P Kurup

Abstract

There has been considerable variability reported in latex extracts used for skin testing and the results of those skin tests in the evaluation of latex allergy. Some test extracts have been associated with the induction of anaphylactic reactions in sensitive patients, while others have been reported as without adverse reactions. The present study was designed to evaluate late extracts by comparing antigens from latex gloves. Latex gloves were extracted for from 15 minutes to 24 hours for their protein contents and in vitro reactivities with IgE antibodies using sera of latex allergic patients and controls by ELISA. A higher yield of proteins was obtained after prolonged extraction, although reactivity of the sera by ELISA showed no major differences among the extracts. Extracts of 15 minutes elicited stronger reaction with health care workers and patients with spina bifida than with 24-hour extracts. The 15-minute extract demonstrated comparatively more reactive antigenic components in the fractions representing 3 to 10 and 10 to 30-kDa compared with fractions having less than 3 and over 30-kDa antigens. The study provided no evidence regarding the safety of one latex extract over the other related to time of extraction. The re...Continue Reading

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Citations

Nov 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H NolteL M DuBuske
Jan 11, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P S NielsenH Nolte
Sep 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C PridgeonA M Ward
Aug 5, 2004·American Journal of Infection Control·Denise M KorniewiczManning Feinleib
Feb 4, 1998·The Journal of the American Dental Association·C P HamannK M Sullivan
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NettisA Tursi

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