Nov 1, 1975

Comparative studies of parasympatholytic drugs on stomach (double blind test) and analysis of relation between gastric form and tonus

Arzneimittel-Forschung
N ToheiR Saito

Abstract

Effects of 3 kinds of parasympatholytic drugs (timepidiumbromide, hyoscine-N-butylbromide and prifinium-bromide) and placebo (physiological saline solution) on the gastrointestinal tract were evaluated roentgenographically by double blind technique in a total of 101 male human subjects. The results may briefly be summarized as follows: 1. There were significant differences on hypotonic rate being one of the indexes of the gastric tonus between timepidium-bromide and placebo. The effects of 3 experimental drugs were significantly high as compared with that of placebo on peristaltic movement of the stomach. The effect of timepidium-bromide was significantly different from that of placebo on the site of arrival of barium. 2. The comparison of degrees of the gastric tonus between main and control tests revealed that the effect of placebo obtained in the main test was significantly inferior to that of hyoscine-N-butylbromide obtained in the control test, whereas there existed no significant differences of the effects among 3 active drugs. 3. Effects of each drug on the gastric tonus which was scored by hypertonic, normotonic and hypotonic state were evaluated by stratification. The result showed that the effect of timepidium-bromide...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Paraparesis
Stochastic Processes
Thiophenes
Pyrrolidines
Piperidines
Muscle Tonus
Clinical Trials
Adhesiveness
Intestinal Motility
Antispasmodic Effect

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.