Comparative studies of ribosomal proteins and their genes from Methanococcus vannielii and other organisms

Canadian Journal of Microbiology
A K Köpke, B Wittmann-Liebold

Abstract

Using data from a partial protein sequence analysis of ribosomal proteins derived from the archaebacterium Methanococcus vannielii, oligonucleotide probes were synthesized. The probes enabled us to localize several ribosomal protein genes and to determine their nucleotide sequences. The amino acid sequences that were deduced from the genes correspond to proteins L12 and L10 from the rif operon, according to the genome organization in Escherichia coli, and to proteins L23 and L2, which have comparable locations, as in the Escherichia coli S10 operon. Various degrees of similarity were found when the four proteins were compared with the corresponding ribosomal proteins of prokaryotic or eukaryotic organisms. The highest sequence homology was found in counterparts from other archaebacteria, such as Halobacterium marismortui, Halobacterium halobium, or Sulfolobus. In general, the M. vannielii protein sequences were more related to the eukaryotic kingdom than to the Gram-positive or Gram-negative eubacteria. On the other hand, the organization of the ribosomal protein genes clearly follows the operon structure of the Escherichia coli genome and is different from the monocistronic eukaryotic gene arrangements. The protein coding regi...Continue Reading

Citations

Apr 20, 1995·Molecular & General Genetics : MGG·J MooreK Kaiser
Jan 1, 1991·Bio Systems·D G Searcy, W G Hixon
Jan 6, 1992·Biochimica Et Biophysica Acta·G HarauzD Flannigan
Jun 15, 1992·Biochemical and Biophysical Research Communications·Y L Chan, I G Wool

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