PMID: 20650057Feb 1, 1995Paper

Comparative studies of the actin cytoskeleton response to maitotoxin and okadaic acid

Toxicology in Vitro : an International Journal Published in Association with BIBRA
G DiogèneS Puiseux-Dao

Abstract

The specific cytotoxic effects of phycotoxins on BHK 21 C13 fibroblasts in culture were studied with maitotoxin (MTX), okadaic acid (OA) and crude extracts from Gambierdiscus toxicus Adachi and Fukuyo and Prorocentrum lima Ehrenberg. These dinoflagellates produce MTX and OA respectively. MTX and G. toxicus crude extracts caused large blebs within minutes after exposure, in a dose-dependent manner. F-actin fibres decreased in number, then disappeared. An increase in fluorescence was observed at the periphery of the nucleus. For one strain of G. toxicus F-actin granules were also observed. Cells exposed to OA or P. lima crude extracts became polygonal in shape and then round. At low doses this effect occurred only after a 24-hr exposure. F-actin fibres crossing the cytoplasm were reduced in size and number then disappeared, while peripheral F-actin fibres became shorter giving the cell first a polygonal and then a round shape. According to these specific responses we have defined an MTX-like effect which is distinct from an OA-like effect. In both cases the amount of F-actin diminished at doses that did not affect cell viability.

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Citations

Feb 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·N BouaïchaP Sandra
Jun 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·N BouaïchaP Sandra
Jul 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·Y F PouchusJ F Verbist
May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T OkadaM Shimizu
Aug 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A NaraiM Shimizu
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A CaillaudJ Diogène
Jul 29, 2008·Toxicon : Official Journal of the International Society on Toxinology·Elisabeth Cañete, Jorge Diogène
Jan 15, 2013·Toxicon : Official Journal of the International Society on Toxinology·William C HollandPatricia A Tester
Feb 7, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jeanete L NavesJosé C Freitas

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