PMID: 8980638Dec 6, 1996Paper

Comparative studies of the fate of free and liposome-entrapped hydroxypropyl-beta-cyclodextrin/drug complexes after intravenous injection into rats: implications in drug delivery

Biochimica Et Biophysica Acta
B McCormack, G Gregoriadis

Abstract

Inclusion complexes of 14C-labelled hydroxypropyl-beta-cyclodextrin (HP beta-CD) with tritiated dehydroepiandrosterone (DHEA), retinol (RET) and dexamethasone (DEX) were entrapped in the aqueous phase of liposomes composed of distearoyl phosphatidylcholine. Incubation of liposome-entrapped complexes in the presence of rat blood plasma at 37 degrees C resulted in complex dissociation and drug leakage in the media at a rate which was minimal for DEX/HP beta-CD (11%), modest for RET/HP beta-CD (23%) and considerable for DHEA/HP beta-CD (56%; 60 min). In contrast, the HP beta-CD moiety of the complexes was retained by liposomes quantitatively. Free complexes injected intravenously into rats were cleared rapidly from the circulation with most (up to 94%) of the HP beta-CD moiety recovered in 24 urine together with lesser and variable amounts of drug (up to 46% of the dose) in a pattern (DHEA < RET < DEX) that was consistent with the extent of drug association with HP beta-CD in the presence of plasma. A significant proportion of the drugs (up to 25% of the dose)(but very little HP beta-CD) was removed by the liver where drugs were catabolised rapidly, probably following complex dissociation and transport to the tissue via plasma pro...Continue Reading

Citations

Jul 22, 2008·Pharmaceutical Research·Vijay Joguparthi, Bradley D Anderson
Aug 24, 2001·Chemistry and Physics of Lipids·I LancrajanM Zorn-Kruppa
Aug 15, 2002·International Journal of Pharmaceutics·Stéphane GibaudAlain Astier
Jun 1, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D G FatourosS G Antimisiaris
Oct 24, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·D Wray-CahenN C Steele
Feb 23, 2010·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·K V ShevchenkoN F Myasoyedov
Dec 16, 2005·AAPS PharmSciTech·Rajeswari ChallaR K Khar
Jul 23, 2011·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·H AgasheV Awasthi
Jan 23, 2016·Pharmaceutical Development and Technology·Eleni KontogiannidouDimitrios G Fatouros
Feb 12, 2008·Journal of Colloid and Interface Science·Hyung Jun LimJunoh Kim
Jul 22, 2008·Magnetic Resonance in Chemistry : MRC·Luís Fernando CabeçaAnita Jocelyne Marsaioli
Apr 1, 2011·Magnetic Resonance in Chemistry : MRC·Luís Fernando CabeçaAnita Jocelyne Marsaioli
Nov 15, 2006·International Journal of Pharmaceutics·Panayiota HatziSophia G Antimisiaris
Feb 5, 2014·Expert Opinion on Drug Delivery·Jun ChenXi-Xiong Yang
Jan 6, 2006·Chemical & Pharmaceutical Bulletin·Yoshiyuki HagiwaraKaneto Uekama
Dec 8, 2000·Pharmaceutical Development and Technology·K K Chakraborty, S R Naik
Mar 22, 2020·Journal of Bioenergetics and Biomembranes·Caroline Deckmann NicolettiVitor Francisco Ferreira
Oct 24, 2009·Journal of Liposome Research·Carla GasbarriAntonella Fontana
Feb 23, 2020·International Journal of Pharmaceutics·Xiao WuVéronique Rosilio

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