Comparative studies of the pathogenesis, antibody immune responses, and homologous protection to porcine and human rotaviruses in gnotobiotic piglets

Advances in Experimental Medicine and Biology
Linda J SaifT To

Abstract

Gnotobiotic piglets serve as a useful animal model for studies of rotavirus pathogenesis and immunity. An advantage over laboratory animal models is the prolonged susceptibility of piglets to rotavirus-induced disease, permitting an analysis of cross-protection and active immunity. Studies from our laboratory of the pathogenesis of human rotavirus infections in gnotobiotic piglets have confirmed that villous atrophy is induced in piglets given virulent but not attenuated human rotavirus (Wa strain) and have revealed that factors other than villous atrophy may contribute to the early diarrhea induced. To facilitate and improve rotavirus vaccination strategies, it is important to identify correlates of protective immunity. Comparison of antibody immune responses induced by infection with virulent porcine and human rotaviruses (mimic host response to natural infection) with those induced by live attenuated human rotavirus (mimic attenuated oral vaccines) in the context of homotypic protection has permitted an analysis of correlates of protective immunity. Our results indicate that the magnitude of the immune response is greatest in lymphoid tissues adjacent to the site of viral replication (small intestine). Secondly there was a d...Continue Reading

Citations

Mar 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anastasia N VlasovaLinda J Saif
Nov 12, 2014·Annual Review of Animal Biosciences·Kuldeep S ChatthaLinda J Saif
Jun 23, 2018·BMC Gastroenterology·Anand KumarGireesh Rajashekara
Sep 10, 2016·World Journal of Gastroenterology : WJG·Jin-Tao LiYu-Zhang Wu
Aug 28, 2021·International Journal of Molecular Sciences·Patricia GogeschMartina Anzaghe

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