Comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat

British Journal of Pharmacology
H R MorrisJ R Tippins


1 Slow-reacting substance of anaphylaxis (SRS-A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea-pig lung. 2 A slow-reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187. 3 These substances were extensively purified by charcoal adsorption, Sephadex G-15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. 4 The three substances are pharmacologically, chemically and chromatographically indistinguishable. 5 Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis.


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In Vitro [Publication Type]

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.