Comparative studies on rat primary cultured and isolated hepatocytes in the evaluation of a therapeutic agents for liver disease

Japanese Journal of Pharmacology
K SakamotoT Kasahara

Abstract

We have investigated the effect of a therapeutic agent for liver disease, Laennec, on the GOT leakage from freshly isolated and primary cultured rat hepatocytes which were treated with CCl4. By treatment with Laennec together with CCl4, the GOT leakage from isolated hepatocytes increased and that from cultured hepatocytes decreased, compared to those incubated only with CCl4. The results suggest that it is better to use primary cultured hepatocytes than to use freshly isolated hepatocytes to evaluate therapeutic agents for liver disease.

Citations

Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G M GroothuisD K Meijer
Oct 4, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Kang-Kon LeeMoon-Jong Kim
Dec 20, 2007·Menopause : the Journal of the North American Menopause Society·Mi-Hee KongSat-Byul Park
Oct 2, 2015·Scientific Reports·Maho NagataShigeru Kinoshita
Mar 11, 2020·Alcoholism, Clinical and Experimental Research·Hyun-Jin KimJu-Seop Kang

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