PMID: 6090264Aug 1, 1984Paper

Comparative studies on the effects of cholecystokinins, caerulein, bombesin 6-14 nonapeptide, and physalaemin on gastric secretion in the ascidian Styela clava

General and Comparative Endocrinology
M C Thorndyke, P J Bevis

Abstract

The effects of cholecystokinins (CCK), caerulein, bombesin 6-14 nonapeptide (bombesin), and physalaemin on gastric secretion in Styela clava were measured using a perfusion technique. Varying concentrations of both CCK33 and CCK8 produced a significant dose-dependent response. Dose for dose, CCK33 was more potent than CCK8, while the assay was unable to show any discrimination between sulphated and nonsulphated forms of CCK8. The specific CCK inhibitor Bt2cGMP significantly reduced the response to both CCK33 and CCK8. Both caerulein and physalaemin were effective although with a considerably reduced response compared with CCK. Bombesin was the most potent of all secretagogues tested while glucagon was without effect on gastric secretion. It is suggested that the primitive prepancreatic zymogen cells in Styela possess a receptor or receptors with an ability to recognize those peptides which are also active on vertebrate pancreatic acinar cells. It is further suggested that while the results indicate a receptor system less sophisticated than that found in vertebrates, they also imply the presence of an endogenous polypeptide hormone or hormones with a sequence which might be expected to show similarities to more than one vertebra...Continue Reading

References

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R T JensenJ D Gardner
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R T Jensen, J D Gardner
Jan 1, 1979·Annual Review of Physiology·G J Dockray
Jul 1, 1979·General and Comparative Endocrinology·S R Vigna, A Gorbman
Feb 14, 1978·Cell and Tissue Research·M C Thorndyke, P J Bevis
Dec 1, 1981·General and Comparative Endocrinology·P J Bevis, M C Thorndyke

Related Concepts

HCl of bombesin nonapeptide
Bombesin Dihydrochloride
Takus
Structure of Pyloric Gland
Glucagon
Kinins
Peptide Fragments
Polypeptides
Physalaemin
Kinevac

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.