PMID: 7034018Nov 1, 1981Paper

Comparative studies on the hemodynamic effects of prostaglandin E1 prostacyclin, and tolazoline upon elevated pulmonary vascular resistance in neonatal swine

Prostaglandins and Medicine
M B StarlingR B Elliott

Abstract

Forty-eight hour old anesthetised and ventilated neonatal piglets were cannulated in order to measure pressure, blood gases and cardiac outputs (CO) from which pulmonary (PVR) and systemic (SVR) vascular resistances were calculated. After baseline measurements had been made inspired gases were altered to produce hypoxemia and hypercapnia, to raise PVR. Animals then received Prostaglandin E1 (PGE1), Tolazoline (TOL), and Prostacyclin (PGI2) in varying dosages until PVR was reduced or the dosage no longer tolerated. With "hypoxia" CO, PVR and pulmonary artery (PA) pressures rose; aortic pressure also rose although SVR tended to fall. PGE1 (5microgram/kg/min) and PGI2 (1.0 microgram/kg/min) both produced a significant fall in PVR. The decrease in PVR with TOL (1 mg/kg/10 minutes and 2 mg/kg/1 hour) was less consistent and in surviving animals did not achieve statistical significance by multivariate analysis. SVR fell with all drugs although the change with TOL was again non-significant. With both PGI2 and TOL there was a trend for CO to rise and, although this did not reach significant levels, it restricted the drop in arterial pressure to approximately control levels. The fall in arterial pressure with PGE1 was greater. The death...Continue Reading

References

Dec 1, 1979·Prostaglandins·R GreenH Sundell
Feb 1, 1979·Archives of Disease in Childhood·N McIntosh, R O Walters
Oct 1, 1979·The Journal of Pediatrics·J E LockP M Olley
Feb 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·S CassinR Wallis

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·P MoninP L Morselli
May 1, 1990·Journal of Clinical Anesthesia·W R Clarke
Feb 1, 1987·World Journal of Surgery·K F Messmer
Dec 26, 2001·The British Journal of Nutrition·S Birkett, K de Lange
Jul 6, 2013·Zoonoses and Public Health·C MesekoG Cattoli

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