PMID: 2498505Jan 1, 1989Paper

Comparative studies on the inducing effects of cobalt chloride and co-protoporphyrin on hepatic ornithine decarboxylase and heme oxygenase in rats

Journal of Pharmacobio-dynamics
S NumazawaY Kuroiwa

Abstract

Co-protoporphyrin, like Co2+, produced a significant and persistent induction of hepatic ornithine decarboxylase (ODC) as well as its known inducing effect on heme oxygenase and the decreasing effects on drug-metabolizing enzymes. The induction of ODC and heme oxygenase by Co-protoporphyrin occurred dose-dependently with the lowest effective dose of 6.25 mumol/kg. Although Co-protoporphyrin produced similar effects on ODC and heme oxygenase to Co2+, there were differences in the mode of ODC induction. In particular, pretreatment with diethyl maleate failed to augment the induction of ODC by Co-protoporphyrin. Moreover, multiple administrations of Co2+, but not Co-protoporphyrin, caused super-additive induction of ODC to about 1000-fold over the controls. This super-additive induction of ODC by Co2+ was dependent on the doses and time intervals between two administrations. In parallel with a large induction of ODC evoked by two administrations of Co2+, hepatic putrescine content was increased markedly, while spermine content was decreased as compared to the control levels. Pretreatment with Co2+ led to super-additive induction of ODC by subsequent administration of the metal ion itself or diethyl maleate, but not by other ODC in...Continue Reading

Citations

Oct 28, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sheng XuWen-Biao Shen
Mar 7, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Tania Y ChristovaMilka S Setchenska
Jan 1, 1989·Chemico-biological Interactions·S NumazawaY Kuroiwa

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