Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells

Biomaterials Research
Gopinathan JanarthananInsup Noh

Abstract

Hybrid scaffolds combining biodegradable polymers and ceramic particles for control of cell adhesion and proliferation are interesting materials for tissue engineering applications. Combinations of biodegradable polymers and ceramics are to provide higher beneficial functionalities to tissue engineering scaffolds with addition of different cell specific bio-factors. Many such hybrid combinations have been reported by several researchers around the world by using various methods and solvents as well as bioactive matrix polymers to fabricate such biomaterials. However, thin hybrid scaffolds with high porosity, cell adhesion factors and biodegradability, as well as the ability to support stem cells often require tedious processes like electrospinning, freeze drying, etc. A simple method to develop porous biodegradable hybrid scaffolds with proper cell adhesion factors is still the need of the hour in tissue engineering and regenerative medicine. Thin biodegradable poly(ε-caprolactone) (PCL) based hybrid scaffolds were developed in combination with α-tricalcium phosphate (TCP) particles, gelatin and fibronectin separately and the fabricated scaffolds were evaluated systematically using human mesenchymal stem cells (hMSCs) for tissu...Continue Reading

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Citations

Jul 30, 2020·Journal of Biomaterials Science. Polymer Edition·Zhonghua XuQingyu Wu
Mar 18, 2021·Biochemical Society Transactions·H AgnierayL J Domigan
Dec 5, 2021·Journal of Materials Science. Materials in Medicine·Mary Josephine McIvorBrian J Meenan

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Methods Mentioned

BETA
X-ray
light microscopy

Software Mentioned

SPSS

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