Comparative study between fast and slow induction of propofol given by target-controlled infusion: expected propofol concentration at the effect site. Randomized controlled trial

Revista brasileira de anestesiologia
Ricardo Francisco SimoniLuis Henrique Cangiani

Abstract

studies have shown that rate of propofol infusion may influence the predicted propofol concentration at the effect site (Es). The aim of this study was to evaluate the Es predicted by the Marsh pharmacokinetic model (ke0 0.26min(-1)) in loss of consciousness during fast or slow induction. the study included 28 patients randomly divided into two equal groups. In slow induction group (S), target-controlled infusion (TCI) of propofol with plasma, Marsh pharmacokinetic model (ke0 0.26min(-1)) with target concentration (Tc) at 2.0-μg.mL(-1) were administered. When the predicted propofol concentration at the effect site (Es) reached half of Es value, Es was increased to previous Es + 1μg.mL(-1), successively, until loss of consciousness. In rapid induction group (R), patients were induced with TCI of propofol with plasma (6.0μg.ml(-1)) at Es, and waited until loss of consciousness. in rapid induction group, Tc for loss of consciousness was significantly lower compared to slow induction group (1.67±0.76 and 2.50±0.56μg.mL(-1), respectively, p=0.004). the predicted propofol concentration at the effect site for loss of consciousness is different for rapid induction and slow induction, even with the same pharmacokinetic model of propofol...Continue Reading

References

Mar 1, 1989·British Journal of Anaesthesia·H SchwildenJ Schüttler
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Aug 6, 1999·British Journal of Anaesthesia·M WhiteG N Kenny
Oct 25, 2003·Anesthesiology·Michael J Avram, Tom C Krejcie
Sep 21, 2004·British Journal of Anaesthesia·R N UptonG L Ludbrook
Oct 27, 2004·Anesthesiology·Anthony G DoufasDaniel I Sessler
Aug 28, 2007·Anesthesiology·Michel M R F StruysSteven L Shafer
Jan 16, 2008·Clinical Pharmacokinetics·Martin WhiteStefan Schraag
Dec 17, 2009·Acta Anaesthesiologica Scandinavica·P O SepúlvedaH R Muñoz

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