Comparative Study Between Lidocaine Gel 2% and 5% for Ophthalmic Procedures

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Hélio Francisco ShiromaEduardo Buchele Rodrigues

Abstract

To compare same-day pain control and safety of 2 different anesthetic gels utilizing 5% and 2% lidocaine gel. Main outcome is to determine whether 5% lidocaine gel is more effective in decreasing pain during conjunctival clamping compared to 2% lidocaine gel 5 and 10 min after gel application. This is a prospective, randomized double-blind clinical trial. Patients were randomized to receive 2% or 5% lidocaine gel in each eye. Discomfort during the gel instillation and pain during conjunctival clamping 5 and 10 min after gel application were compared. Extent of corneal conjunctival staining was graded according to the Oxford scale. Eighty eyes of 40 patients were enrolled. The groups were similar in gender, with a mean age of 48 ± 16.26 years. The 5% lidocaine gel resulted in higher discomfort during initial instillation (P = 0.092), however, the pain during conjunctival clamping was lower in the 5% lidocaine gel eyes (P = 0.564) in both 5 and 10 min later (P < 0.001). The majority of patients (80%) had no corneal conjunctival dye staining. The tear break-up time was not statistically different after lidocaine gel 2% (20.35 ± 7.37 s) and lidocaine 5% (19.75 ± 7.00 s). Five percent and 2% lidocaine gel have similar efficacy contr...Continue Reading

References

Jul 1, 1986·British Journal of Anaesthesia·B G Covino
May 20, 1999·Journal of Cataract and Refractive Surgery·I S BarequetT P O'Brien
Sep 7, 1999·Journal of Cataract and Refractive Surgery·R SunH V Gimbel
Oct 31, 2007·Expert Opinion on Drug Safety·Hall T McGee, F W Fraunfelder
Oct 4, 2008·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Brandon G BusbeeElias Reichel
Jun 3, 2009·Revista brasileira de anestesiologia·Almiro dos Reis
Aug 30, 2014·Expert Opinion on Drug Safety·Helio Francisco ShiromaEduardo Buchelle Rodrigues
Sep 6, 2014·European Journal of Anaesthesiology·Philipp LirkMarkus W Hollmann

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
Akten

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