Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

AAPS PharmSciTech
Ali Nazarizadeh, Siamak Asri-Rezaie

Abstract

In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO4) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.

References

Jul 1, 1970·Physiological Reviews·A Deisseroth, A L Dounce
Sep 1, 1993·Canadian Journal of Physiology and Pharmacology·W J Bettger
Aug 13, 1998·The American Journal of Clinical Nutrition·A H Shankar, A S Prasad
Oct 29, 2000·Annals of Nutrition & Metabolism·M A El-Missiry, A M El Gindy
Dec 21, 2000·Free Radical Biology & Medicine·A GhiselliC Scaccini
Feb 22, 2001·Free Radical Biology & Medicine·M C PolidoriH Sies
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
May 14, 2003·The Journal of Biological Chemistry·Weidong WuAndrew J Ghio
May 4, 2004·Journal of Nanobiotechnology·OV Salata
Sep 29, 2004·Free Radical Biology & Medicine·Ananda S PrasadFazlul H Sarkar
Mar 4, 2005·Treatments in Endocrinology·Dominique Bonnefont-Rousselot
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ye SongLu Cai
Jan 1, 1934·The Biochemical Journal·D A Scott
Sep 16, 2006·Archives of Biochemistry and Biophysics·Philippe L WalterLars-Oliver Klotz
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan B G LansdownMagnus S Agren
Aug 30, 2007·Annals of Nutrition & Metabolism·Eva S WintergerstDietrich H Hornig
Dec 7, 2007·BioFactors·Md Shahidul Islam, Du Toit Loots
Jan 15, 2008·Biological Trace Element Research·Tasneem Gul KaziGhulam Abbas Kandhro
Apr 17, 2009·The Journal of Nutritional Biochemistry·Yunan TangLu Cai
Apr 22, 2009·Toxicology Letters·Vyom SharmaAlok Dhawan
May 16, 2009·The Journal of Nutritional Biochemistry·Judith JansenLothar Rink
May 19, 2009·Toxicology Letters·Hanna L KarlssonLennart Möller
Mar 8, 2012·Apoptosis : an International Journal on Programmed Cell Death·Vyom SharmaAlok Dhawan
Dec 26, 2012·Journal of Inorganic Biochemistry·George VardatsikosAshok K Srivastava
Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Sep 1, 1995·Mycotoxin Research·R F VesonderS W Peterson
Jan 1, 2012·Nanotechnology, Science and Applications·Rob J Vandebriel, Wim H De Jong
Jan 31, 2014·International Journal of Molecular Sciences·Ali AlkaladiMohamed Afifi
Mar 29, 2014·Journal of Food and Drug Analysis·Peter P FuHongtao Yu
Sep 23, 2014·Applied Biochemistry and Biotechnology·Pandurangan MuthuramanDoo Hwan Kim

❮ Previous
Next ❯

Citations

Oct 5, 2013·Particle and Fibre Toxicology·Alexandra NoëlGinette Truchon
May 20, 2017·Current Diabetes Reviews·Zenith KhashimKathiravan Krishnan
Jul 25, 2019·Current Pharmaceutical Design·Xavier-Ravi BaskaranWenbo Liao
Apr 25, 2018·Nanomaterials·Marina Martínez-CarmonaMaría Vallet-Regí
Dec 18, 2019·Biological Trace Element Research·Mohamed S OthmanAhmed E Abdel Moneim
Mar 25, 2020·Environmental Science and Pollution Research International·Amira A Bauomy
Aug 4, 2018·Bioinorganic Chemistry and Applications·Jinhuan JiangJiye Cai
Aug 16, 2018·Biological Trace Element Research·Tao KongBai-Hao Zhang
Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Oleh LushchakAlexander Vaiserman
Oct 9, 2020·Biological Trace Element Research·Faria FatimaWaqar Ahmad Khan
Nov 13, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Reham Z HamzaNahla S El-Shenawy
Aug 27, 2019·International Journal of Biological Macromolecules·Jihan HusseinMehrez E El-Naggar
Oct 15, 2020·Reviews in Endocrine & Metabolic Disorders·Rout George KerrySabuj Sahoo
May 7, 2020·Diabetes & Metabolic Syndrome·Hadis AshrafizadehAli Akbar Oroojan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.