PMID: 8451600Feb 1, 1993Paper

Comparative study of atrial peptides ANF (1-98) and ANF (99-126) as diagnostic markers of atrial distension in patients with cardiac disease

Scandinavian Journal of Clinical and Laboratory Investigation
P MathisenS Simonsen

Abstract

To evaluate the possible role of atrial natriuretic peptides ANF (1-98) and ANF (99-126) as diagnostic parameters of atrial distension, measurements of peptide levels were performed in 47 patients with chronic ischemic and/or left sided valvular heart disease. Plasma samples were drawn from the pulmonary artery (PA) and superior vena cava (SVC) during diagnostic right heart catheterization. Forty of the patients also underwent left heart haemodynamic measurements, and in 28 patients two dimensional echocardiography with determination of left atrial diameter was performed. Enhanced plasma concentrations of both peptides were observed with increasing severity of heart failure assessed by the NYHA classification. Mean plasma levels of both peptides were closely correlated to mean pulmonary artery pressure (ANF (1-98): n = 47, r = 0.69 (SVC)/r = 0.72 (PA), p < 0.0001; ANF (99-126): n = 46, r = 0.75 (SVC)/r = 0.68 (PA), p < 0.0001) and mean pulmonary capillary wedge pressure (ANF (1-98): n = 47, r = 0.69 (SVC)/r = 0.72 (PA), p < 0.0001; ANF (99-126): n = 46, r = 0.70 (SVC)/r = 0.64 (PA), p < 0.0001). Positive correlations were also obtained between peptide levels and mean right atrial pressure and left ventricular end-diastolic pres...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jan 30, 1990·Biochemical and Biophysical Research Communications·Y M ChenN M Cintrón
Aug 16, 1986·British Medical Journal·A M RichardsJ I Robertson
Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·K HasegawaT Yamaji
Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·F SatoT Yamaji
Jan 1, 1987·Circulation·P BolliF R Bühler
Jan 30, 1987·Biochemical and Biophysical Research Communications·R TakayanagiT Inagami
Jan 1, 1987·The Biochemical Journal·G ThibaultM Cantin
Jan 15, 1988·Biochemical and Biophysical Research Communications·C J WintersD L Vesely
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J A SundsfjordM Cantin
Jul 1, 1985·Hypertension·P NeedlemanD G Standaert
Oct 3, 1985·The New England Journal of Medicine·H NakaokaT Yamaji
Dec 28, 1983·Biochemical and Biophysical Research Communications·T G FlynnA J de Bold
Jan 13, 1984·Biochemical and Biophysical Research Communications·K Kangawa, H Matsuo

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Citations

Apr 20, 2005·Regulatory Peptides·Ana M PuyóBelisario E Fernández
Mar 14, 2002·Regulatory Peptides·Ana M PuyóBelisario E Fernández
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Sandeep ChopraJubbin J Jacob
Dec 1, 1994·American Journal of Obstetrics and Gynecology·L C CastroJ Gornbein
Apr 24, 2013·The Journal of Surgical Research·Eriphyli ArgyraGeorge Polymeneas
Nov 23, 2007·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Heidrun GehlenPeter Stadler
Apr 22, 2009·Congestive Heart Failure·Maria da Consolação V MoreiraThomas Walther
Apr 13, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·H SchulzC Hall
Jun 18, 1998·American Heart Journal·M K BaigM Gheorghiade
May 1, 1995·European Journal of Clinical Investigation·G McDowellD P Nicholls
Aug 24, 2010·European Journal of Gastroenterology & Hepatology·Javier PadilloManuel De la Mata
Aug 23, 2002·European Journal of Clinical Investigation·G McDowellC Hall
Apr 1, 1997·Medicine and Science in Sports and Exercise·L GullestadS Simonsen
Dec 13, 2007·Cardiology·Maria da Consolação V MoreiraThomas Walther
Mar 17, 1999·Heart & Lung : the Journal of Critical Care·M K BaigM Gheorghiade
Jul 9, 2021·Biomedical Journal·Mengjiao XuGeng Yang
Jun 10, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Prasanna K SanthekadurArun J Sanyal

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