Comparative study of autologous stromal vascular fraction and adipose-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury

Stem Cells Translational Medicine
Dalsan YouChoung-Soo Kim

Abstract

The abilities of intracavernous injection of autologous stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) to facilitate recovery of erectile function in a rat model of cavernous nerve (CN) injury were compared. Forty male Sprague-Dawley rats were randomly divided into four groups: sham and control groups (intracavernous injection of phosphate-buffered saline), SVF group (intracavernous injection of SVF), and ADSC group (intracavernous injection of ADSCs). Rats in the latter three groups underwent bilateral CN injury prior to injection. The evaluation of erectile function and histomorphometric studies were performed 4 weeks after injection. The ratio of maximal intracavernous pressure to mean arterial pressure was significantly lower in the control group than in the sham group (0.18 vs. 0.56, p < .001). Intracavernous injection of SVF (0.36, p = .035) significantly improved erectile function compared with that in the control group, whereas the ADSC group (0.35, p = .052) showed marginally significant improvement. The smooth muscle/collagen ratio, smooth muscle content, number of neuronal nitric-oxide synthase-positive nerve fibers, and expression of von Willebrand factor were significantly higher in the SVF ...Continue Reading

References

Aug 1, 1997·The Journal of Urology·L T KleinR Shabsigh
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 14, 2003·Journal of Andrology·Somboon LeungwattanakijWayne J G Hellstrom
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffery W SaranchukJames A Eastham
May 24, 2007·Tissue Engineering·Bonnie BarrilleauxKim C O'Connor
Feb 12, 2009·The Journal of Sexual Medicine·Hongxiu NingChing-Shwun Lin
Mar 17, 2009·The Journal of Sexual Medicine·Guiting LinTom F Lue
Mar 14, 2009·Differentiation; Research in Biological Diversity·Hongxiu NingChing-Shwun Lin
Apr 28, 2009·Journal of Translational Medicine·Neil H RiordanBoris Minev
Jan 5, 2011·Cell Proliferation·A WilsonA M Seifalian
May 25, 2011·World Journal of Stem Cells·Louis CasteillaBéatrice Cousin
Mar 9, 2012·Regenerative Medicine·Jeffrey M GimbleFarshid Guilak
Oct 5, 2013·Expert Opinion on Biological Therapy·Ching-Shwun LinTom F Lue
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Dec 24, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Lauren E KokaiJ Peter Rubin

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Citations

Jan 14, 2016·Current Opinion in Urology·M Ayodhia SoebadiMaarten Albersen
Jan 4, 2017·Sexual Medicine Reviews·Mohammad Ayodhia SoebadiMaarten Albersen
Oct 12, 2018·Expert Opinion on Biological Therapy·Serap GurWayne J G Hellstrom
Oct 28, 2018·Nature Reviews. Urology·Uros MilenkovicFabio Castiglione
Mar 25, 2019·Stem Cells Translational Medicine·Stuart P Atkinson
Apr 26, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuan SunMing Pei
Sep 30, 2018·BJU International·Fabio CastiglioneUNKNOWN Trauma and Reconstructive Urology Working Party of the European Association of Urology (EAU) Young Academic Urologists (YAU)
Sep 6, 2017·Current Opinion in Organ Transplantation·Katlin B StiversJames B Hoying
Apr 22, 2020·The Physician and Sportsmedicine·Alessio BiazzoFrancesco Verde
May 18, 2016·Nature Reviews. Disease Primers·Faysal A YafiWayne J G Hellstrom
Jun 5, 2018·Neural Regeneration Research·Rui Zhang, Joseph M Rosen
May 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Vasilena E GetovaMartin C Harmsen
Aug 11, 2020·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Kaoru TadaHiroyuki Tsuchiya
Aug 23, 2018·Hormones : International Journal of Endocrinology and Metabolism·Ioannis VakalopoulosGeorgios Dimitriadis
Jan 10, 2021·Medicines·Vassilis ProtogerouTheodoros Troupis
Oct 24, 2019·Sexual Medicine Reviews·Soum D LokeshwarRanjith Ramasamy
Aug 19, 2021·Trends in Biotechnology·Matthias W Laschke, Michael D Menger

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