PMID: 9161646May 1, 1997Paper

Comparative study of bioavailability and clinical efficacy of carbamazepine in epileptic patients

The Annals of Pharmacotherapy
O SilpakitS Kaojarern

Abstract

To compare the bioavailability of three generic brands of carbamazepine tablets with that of a proprietary brand in adult patients with epilepsy. A double-blind, randomized, three-phase crossover study. A psychiatric facility. Eighteen patients with epilepsy who had taken carbamazepine at least 5 months before entering the study. Ten blood specimens from each patient were collected at steady-state. Plasma concentration of carbamazepine was analyzed for pharmacokinetic parameters such as maximum plasma concentration (Cmax), mean time to reach maximum concentration (tmax), and mean AUC. There were no statistically significant differences in these parameters among four brands of carbamazepine. However, when comparing the 90% CI of AUC of three generic brands with that of the proprietary brand, the AUC of two generic brands lay within a range of 80% to 120%. The effects of gender and each brand of carbamazepine on these pharmacokinetic parameters were also analyzed. Breakthrough seizures occurred even though the plasma concentration of carbamazepine was therapeutic. The bioavailability of two generic brands of carbamazepine tablets (Carmapine and Carzepine) and the proprietary brand (Tegretol) were equivalent in this sample of adul...Continue Reading

References

Nov 1, 1990·Neurology·M R NuwerB J Wilder
Jun 20, 1987·Lancet·R C Sachdeo, G Belendiuk
Jun 1, 1987·Archives of Neurology·G Koch, J P Allen
Jul 1, 1986·Journal of Clinical Pharmacology·L BertilssonG Tybring
Dec 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·C S Locke

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Citations

Nov 26, 2010·Expert Review of Neurotherapeutics·Josemir W SanderJürgen Bauer
Jul 24, 2004·CNS Drugs·Barbara C Jobst, Gregory L Holmes
Aug 1, 2007·Journal of Psychopharmacology·Michael Van AmeringenMark Bennett
Dec 3, 2014·Expert Opinion on Drug Metabolism & Toxicology·Slobodan M Jankovic, Dragana Ignjatovic Ristic
Dec 1, 2010·CNS Neuroscience & Therapeutics·Julie Eve DesmaraisHoward C Margolese
Jun 27, 2008·Current Treatment Options in Neurology·Susan J Shaw, Gregory L Krauss
Apr 27, 2013·CNS Drugs·Maren Carbon, Christoph U Correll
Oct 27, 2011·The Annals of Pharmacotherapy·Mikiko Yamada, Timothy E Welty
Feb 22, 2021·Journal of Pharmaceutical Sciences·Mauricio A GarcíaPeter Langguth

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