PMID: 44765Jan 1, 1979

Comparative study of erythromycin, amoxicillin and ampicillin antimicrobial activity against human respiratory tract pathogens

Scandinavian Journal of Infectious Diseases. Supplementum
R H LissD A Goldmann

Abstract

An in vitro test system was used to compare the antimicrobial activity of erythromycin, amoxicillin and ampicillin against respiratory tract pathogens isolated from man. The minimum inhibitory concentrations (MICs) of fresh clinical isolates of Streptoccus pyogenes, Streptocuccus pneumoniae, Staphylococcus aureus and Haemophilus influenzae to the macrolide and penicillins ranged between 0.01 and 0.9 microgram/ml. The microbes were exposed to each antibiotic for approximately 3 h at 1x,2x and 5x the relevant MIC. Irreversible surface defects and intracellular lesions were resolved by scanning and transmission electron microscopy in all antibiotic-treated bacterial species, irrespective of the antimicrobial used. In each case, inhibition of growth was recorded by turbometric assay; no significant difference was observed among the declining slopes of post-dosing growth curves for either erythromycin-, amoxicillin- or ampicillin-treated pathogens. The experimental observations show that the onset of antimicrobial activity and the bactericidal effectiveness of equipotent concentrations of erythromycin, amoxicillin and ampicillin were comparable in this study. The results complement previous clinical, bacteriologic and ultrastructure...Continue Reading

References

Jun 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·N Frimodt-Møller, V F Thomsen

Citations

Dec 1, 1977·Scottish Medical Journal·J C Gould
Dec 1, 1977·Scottish Medical Journal·J McC Murdoch
Jan 1, 1974·The American Journal of the Medical Sciences·J L BruschL Weinstein
Oct 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·T H HAIGHT, M FINLAND
May 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·L UNGER, A KISCH

Related Concepts

Erythromycin
Haemophilus influenzae
Mycobacterium Avium-intracellulare Infection
Meningitis, Haemophilus
Respiratory Tract Structure
Amoxicillin
Macrolide Antibiotics
Protoplasm
Wymox
Respiratory System

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