Comparative study of GH-transgenic and non-transgenic amago salmon (Oncorhynchus masou ishikawae) allergenicity and proteomic analysis of amago salmon allergens

Regulatory Toxicology and Pharmacology : RTP
Rika NakamuraReiko Teshima

Abstract

Genetically modified (GM) foods are beneficial from the standpoint of ensuring a constant supply of foodstuffs, but they must be tested for safety before being released on the market, including by allergenicity tests to ensure that they do not contain new allergens or higher concentrations of known allergens than the same non-GM foods. In this study we used GM-amago salmon into which a growth hormone gene had been introduced and compared the allergens contained in the GM and the non-GM-amago salmons. We used a combination of Western blotting with allergen-specific antibodies and a proteomic analysis of their allergens with patients' sera, a so-called allergenome analysis, to analyze allergens. Western blotting with specific antibodies showed no increase in the content of the known allergens fish parvalbumin and fish type-I collagen in GM-amago salmon, in comparison with their content in non-GM-amago salmon. The allergenome analysis of two fish-allergic patients allowed us to identify several IgE-binding proteins in amago salmon, including parvalbumin, triose-phosphate isomerase, fructose-bisphosphate aldolase A, and serum albumin, and there were no qualitative differences in these proteins between GM and non-GM-amago salmons. T...Continue Reading

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Citations

May 28, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eloina González-ManceboCarlos Pastor-Vargas
Mar 2, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rika NakamuraReiko Teshima
Apr 23, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Marina Pérez-GordoJavier Cuesta-Herranz
Feb 27, 2013·Australian Veterinary Journal·K A McCollT J Doran
Jun 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A KuehnF Hentges
May 30, 2014·Clinical Reviews in Allergy & Immunology·María PedrosaSantiago Quirce
Jun 5, 2014·International Journal of Genomics·Xiaohong LiJi-Fu Wei
Feb 9, 2011·Regulatory Toxicology and Pharmacology : RTP·Rie SatohReiko Teshima
Jul 26, 2011·Molecular Immunology·Kerstin BauermeisterGerald Reese
Aug 23, 2011·The Journal of Allergy and Clinical Immunology·Keity Souza SantosFabio Fernandes Morato Castro
May 6, 2014·Frontiers in Immunology·Annette KuehnFrançois Hentges
Jan 11, 2017·Journal of Agricultural and Food Chemistry·Yang YangGuang-Ming Liu
Nov 1, 2018·Veterinary Dermatology·Jennifer BexleyThierry Olivry
Mar 2, 2017·Proteomes·Alexandre M O Campos, André M de Almeida
Aug 30, 2020·Allergy·Thimo RuethersAndreas L Lopata
Jan 23, 2021·Medicina·Betul BuyuktiryakiMaria Andreina Marques-Mejias
Mar 10, 2021·Scientific Reports·Shiori AkimotoHiroaki Matsuo

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