Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?

Neuroimmunomodulation
Christoph J AuernhammerDieter Engelhardt

Abstract

This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined. Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor (CNTF) and novel neurotrophin-1/B-cell stimulating factor-3 (CNTFR alpha/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIF...Continue Reading

Citations

May 19, 2007·Endocrinology·Ryan JankordM Harold Laughlin
Sep 2, 2009·Journal of Neurochemistry·Weihong PanAbba J Kastin
Oct 12, 2010·Medical Hypotheses·Albert Stuart Reece
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiro NagaiTakahiro Yamaguchi
Apr 6, 2011·Journal of Endocrinological Investigation·F Pecori GiraldiF Cavagnini

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