PMID: 6414111Jul 1, 1983Paper

Comparative study of hepatic microsomal and cytosolic enzyme activities in three murine strains

Toxicology Letters
T A DraganiM Presutti

Abstract

A comparative study on hepatic microsomal p-nitroanisole-O-demethylase, aminopyrine-N-demethylase, NADPH-cytochrome c reductase and cytosolic glutathione (GSH) S-transferase was performed in both sexes of C3Hf, C57BL/6J and DBA/2 mice. In control and phenobarbital (PB)-induced mice similarities in hepatic microsomal activities were found with slight variations among strains and sexes. The Ah locus nonresponsive DBA/2 mice showed uninduced microsomal activities after beta-naphthoflavone (BNF), as expected; the other two strains were induced by BNF to a similar extent. Differences in cytosolic GSH S-transferase were detected among strains and sexes; C57BL/6J mice showed the highest basal and induced levels. The males of all the three strains examined were found to have higher GSH S-transferase activity than females.

Citations

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·T A DraganiG Della Porta
May 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J C MirsalisJ E Dabbs

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