Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis

Frontiers in Immunology
Shun MaekawaShih-Chu Chen

Abstract

Transcriptome analysis is a powerful tool that enables a deep understanding of complicated physiological pathways, including immune responses. RNA sequencing (RNA-Seq)-based transcriptome analysis and various bioinformatics tools have also been used to study non-model animals, including aquaculture species for which reference genomes are not available. Rapid developments in these techniques have not only accelerated investigations into the process of pathogenic infection and defense strategies in fish, but also used to identify immunity-related genes in fish. These findings will contribute to fish immunotherapy for the prevention and treatment of bacterial infections through the design of more specific and effective immune stimulants, adjuvants, and vaccines. Until now, there has been little information regarding the universality and diversity of immune reactions against pathogenic infection in fish. Therefore, one of the aims of this paper is to introduce the RNA-Seq technique for examination of immune responses in pathogen-infected fish. This review also aims to highlight comparative studies of immune responses against bacteria, based on our previous findings in largemouth bass (Micropterus salmoides) against Nocardia seriola...Continue Reading

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Citations

Jul 15, 2020·Journal of Fish Diseases·Shun MaekawaShih-Chu Chen

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Methods Mentioned

BETA
RNA-Seq
PCR

Software Mentioned

ID Converter Systems
Trinity
DAVID

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