Comparative study of inflammatory and non-inflammatory locally advanced breast cancer - the experience of a Moroccan hospital

Gynécologie, Obstétrique, Fertilité & Sénologie
Z BenbrahimS Arifi

Abstract

The locally advanced breast cancer (LABC) covers large tumor heterogeneity. It consists of non-inflammatory LABC and inflammatory breast cancer (IBC). This study aimed to compare the epidemiological, clinical and pathological, as well as the prognosis of IBC versus non-inflammatory LABC. This is a retrospective study of 150 cases of IBC and non-inflammatory LABC collected in medical oncology department of the CHU Hassan II of Fez during a period of 4 years [January 2009-January 2013]. Overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. Analysis of the various prognostic factors was performed according to the Cox model. IBC represented 28.7% of LABC. The median age was 47 years. The median tumor size was greater in non-inflammatory LABC compared with IBC (9.5 versus 6cm; P=0.0014). Lymph node invasion was more common in the IBC (49.7% versus 45.9%; P=0.01). An SBR grade 3 was more frequently noted in the IBC (P=0.011). The two groups were well balanced with regard to HR, HER2 status and pathologic complete response. Non-inflammatory LABC had the best OS and DFS (24 vs. 22 months; P=0.03 and 18 vs. 17 months; P=0.025 respectively). IBC has a worse prognosis compared to non-inflamma...Continue Reading

References

Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ChangS D Hursting
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KuererS E Singletary
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William F AndersonShine Chang
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer A LowSandra M Swain
Mar 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N CabiogluM Cristofanilli
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen ChiaDavid A Mankoff
Feb 27, 2008·Cancer·Shaheenah DawoodUNKNOWN Inflammatory Breast Cancer Research Group
Sep 8, 2009·Seminars in Radiation Oncology·Wendy A Woodward, Massimo Cristofanilli
Jul 7, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S DawoodM Cristofanilli
Sep 23, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoE Winer
Dec 3, 2014·Critical Reviews in Oncology/hematology·D J P van UdenC F J M Blanken-Peeters

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